急性胰腺炎治疗的新进展
New Advances in the Treatment of Acute Pancreatitis.
作者信息
Faghih Mahya, Fan Christopher, Singh Vikesh K
机构信息
Division of Gastroenterology, Johns Hopkins Medical Institutions, 1830 E. Monument Street, Room 428, Baltimore, MD, 21205, USA.
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
出版信息
Curr Treat Options Gastroenterol. 2019 Mar;17(1):146-160. doi: 10.1007/s11938-019-00223-8.
PURPOSE OF REVIEW
Despite the increasing incidence of acute pancreatitis, the overall mortality of AP has decreased.
RECENT FINDINGS
The findings of recent studies on fluid therapy, analgesics, antibiotics, and enteral nutrition as well as the management of AP complications have led to improvements in clinical care. However, there are still no pharmacologic treatment(s) for AP. Experimental studies have revealed many potential therapeutic targets, but these will need to be further developed and tested before they can be assessed in randomized controlled trials with important clinical endpoints.
综述目的
尽管急性胰腺炎的发病率不断上升，但急性胰腺炎的总体死亡率有所下降。
最新发现
近期关于液体疗法、镇痛药、抗生素、肠内营养以及急性胰腺炎并发症管理的研究结果已使临床护理得到改善。然而，目前仍没有针对急性胰腺炎的药物治疗方法。实验研究已揭示了许多潜在的治疗靶点，但在能够以重要临床终点进行随机对照试验评估之前，这些靶点还需要进一步开发和测试。
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