Nakabayashi Akira, Kanno Toshiyuki, Takahashi Nobuko, Akizawa Yoshika, Onizuka Hiromi, Matsui Hideo
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan.
J Obstet Gynaecol Res. 2019 May;45(5):1079-1083. doi: 10.1111/jog.13887. Epub 2019 Jan 30.
Nephroblastoma (also known as Wilms' tumor) mainly occurs in the kidneys of children. Nephroblastoma outside the kidneys may be observed in three situations: primary disease, metastatic disease and nephroblastoma arising in teratoma. Teratoma with nephroblastoma (TWN) of the adult ovary is a rare tumor and only one case has been reported. We report an unusual adult case of ovarian TWN presented to us with acute abdomen due to the spontaneous rupture of the ovary. The rupture occurred at the site of TWN, while contralateral ovary with only mature cystic teratoma component had no rupture. After one and a half months of the ovary sparing surgery, the tumor disseminated to the splenic hilum and the omentum. A complete staging with maximum cytoreduction followed by adjuvant chemotherapy were performed. She remains disease free until present.
肾母细胞瘤（也称为威尔姆斯瘤）主要发生于儿童肾脏。肾外肾母细胞瘤可见于三种情况：原发性疾病、转移性疾病以及畸胎瘤中发生的肾母细胞瘤。成人卵巢的肾母细胞瘤合并畸胎瘤（TWN）是一种罕见肿瘤，仅报道过1例。我们报告1例不寻常的成人卵巢TWN病例，该患者因卵巢自发破裂以急腹症就诊。破裂发生在TWN部位，而对侧卵巢仅含成熟囊性畸胎瘤成分未发生破裂。在保留卵巢手术1个半月后，肿瘤播散至脾门和大网膜。进行了全面分期并最大程度减瘤，随后进行辅助化疗。她至今仍无疾病复发。
