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心内科临床中渗出性缩窄性结核性心包炎合并关节炎:胸腔镜活检作为一种诊断和治疗方法

Exudative-constrictive tuberculous pericarditis in combination with arthritis in cardiologist practice: thoracoscopic biopsy as a diagnosis and treatment method.

作者信息

Blagova O V, Alijeva I N, Nedostup A V, Kaburova A N, Senchihin P V, Parshin V D, Kogan E A

机构信息

V.N. Vinogradov Faculty Therapeutic clinic of I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

出版信息

Ter Arkh. 2018 Sep 20;90(9):81-87. doi: 10.26442/terarkh201890981-87.

Abstract

AIM

The goal is to present the possibilities of diagnosis verification, the features of the clinical picture of tuberculous pericarditis in the therapeutic clinic and the results of its treatment.

MATERIALS AND METHODS

The paper presents clinical observation and a general analysis of 10 cases of tuberculous pericarditis in patients aged 31-79 (mean age 58.0 ± 15.1 years), 6 women and 4 men. Diagnostic puncture pericardium was performed on two patients, pleural puncture - on three Thoracoscopic biopsy of hilar lymph nodes and lung (n=1), pleura (n=1), supraclavicular lymph node biopsy (n=1). Dyskin test was carried out, as well as sputum examination, multispiral computed tomography, oncological search.

RESULTS

A 31-year-old patient with a massive effusion in the pericardial cavity, pleural lesion, arthritis of the left knee joint, whose results of the pericardial effusion and sputum were not diagnosed, tuberculosis was detected only with thoracoscopic biopsy of the lung and intrathoracic lymph nodes; the treatment via prednisolone and subtotal pericardectomy was performed. Among 10 patients with MSCT of the lung, changes were noted in general, but in only one case they were highly specific. Diaskin test is positive in 70%. In the study of punctata, bronchoalveolar flushing, Koch bacteria were not detected; at sputum in microscopy and biological sample BC was detected in two patients. The lymphocytic character of effusion in the pericardium / pleura is noted in 4 out of 5 cases. At a biopsy of lymphonoduses and a lung at 2 patients the picture of a granulomatous inflammation with a caseous necrosis. Pericarditis was predominantly large (from 2 cm and more) effusion, signs of constriction were noted in 50% of patients.

CONCLUSION

Tuberculosis is one of the frequent causes of pericarditis in the Moscow therapeutic clinic. The most lymphocytic effusion with fibrin and the development of constriction. The negative results of all laboratory tests for tuberculosis do not exclude a diagnosis, It is necessary to use invasive morphological diagnostics, including thoracoscopic biopsy.

摘要

目的

旨在介绍结核性心包炎在治疗性诊所中的诊断验证可能性、临床表现特征及其治疗结果。

材料与方法

本文呈现了对10例年龄在31 - 79岁(平均年龄58.0±15.1岁)的结核性心包炎患者的临床观察及综合分析,其中女性6例,男性4例。对2例患者进行了心包诊断性穿刺,3例进行了胸腔穿刺,1例进行了肺门淋巴结和肺的胸腔镜活检,1例进行了胸膜活检,1例进行了锁骨上淋巴结活检。进行了狄斯金试验,以及痰液检查、多层螺旋计算机断层扫描、肿瘤学检查。

结果

一名31岁患者,心包腔大量积液,伴有胸膜病变及左膝关节关节炎,心包积液和痰液检查结果均未明确诊断,仅通过肺和胸内淋巴结的胸腔镜活检检测出结核;采用泼尼松龙和心包次全切除术进行治疗。10例患者的肺部多层螺旋计算机断层扫描总体有变化,但仅1例具有高度特异性。狄斯金试验70%呈阳性。在对穿刺物、支气管肺泡灌洗物的研究中,未检测到结核杆菌;2例患者痰液显微镜检查及生物样本培养检测到结核杆菌。5例中有4例心包/胸膜积液呈淋巴细胞特征。2例患者的淋巴结和肺活检显示为肉芽肿性炎症伴干酪样坏死。心包炎主要为大量(2厘米及以上)积液,50%的患者有缩窄征象。

结论

在莫斯科治疗性诊所,结核病是心包炎的常见病因之一。最常见的是伴有纤维蛋白的淋巴细胞性积液及缩窄的发展。所有结核病实验室检查结果为阴性并不排除诊断,有必要采用侵入性形态学诊断方法,包括胸腔镜活检。

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