Damulin I V
I.M. First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
A.S Loginov Moscow clinical scientific center of the Moscow healthcare Department, Moscow, Russia.
Ter Arkh. 2018 Feb 15;90(2):89-93. doi: 10.26442/terarkh201890289-93.
The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this condition. The importance of cerebral connections disruption is emphasized. It is focused on the fact that in the functioning of the central nervous system the spontaneous activity of the brain has a significant importance. Separately is analyzed "the resting state". It is concluded that MHE, despite its minimal manifestations, is a clinically significant condition requiring attention of a specialists. With that, it is often not diagnosed on time in clinical practice, which could lead to more severe damage of the cerebral functions. As evidenced by the data obtained at the present time, quite extensive changes in the neuronal activity are underlid of the cognitive deficit.
该综述探讨了关于轻微肝性脑病（MHE）的临床及发病机制的现代观点。讨论了此类患者认知障碍的存在情况。分析了功能磁共振成像的数据，这些结果使人们能够重新审视这种情况下临床病症的起源。强调了脑连接中断的重要性。关注到在中枢神经系统的功能中，大脑的自发活动具有重要意义。单独分析了“静息状态”。得出结论，MHE尽管表现轻微，但却是一种具有临床意义的病症，需要专科医生关注。然而，在临床实践中它常常不能被及时诊断，这可能导致脑功能更严重的损害。目前所获得的数据表明，认知缺陷背后存在相当广泛的神经元活动变化。
