哇巴因在麻醉猫中诱发心律失常的改良方法。

Modified method for the production of cardiac arrhythmias by ouabain in anesthetized cats.

作者信息

Rao T S, Seth S D, Nayar U, Manchanda S C

机构信息

Department of Pharmacology, All-India Institute of Medical Sciences, New Delhi.

出版信息

J Pharmacol Methods. 1988 Nov;20(3):255-63. doi: 10.1016/0160-5402(88)90067-8.

DOI:10.1016/0160-5402(88)90067-8

PMID:3070180

Abstract

A modified method of producing ouabain-induced cardiac arrhythmias in chloralose-anesthetized cats has been developed, whereby prolonged arrhythmias with low incidence of mortality (12%) are observed. Furthermore, the employment of a modified arrhythmia scale in the present model allowed a quantitative estimation of antiarrhythmic efficacy of test drugs and also made it possible to unravel the arrhythmogenic nature of these substances. This improved method could be conveniently used for the quantitative screening of both the antiarrhythmic or the arrhythmogenic nature of test drugs.

摘要

已开发出一种在氯醛糖麻醉的猫身上产生哇巴因诱发心律失常的改良方法，通过该方法可观察到长时间的心律失常，且死亡率较低（12%）。此外，在本模型中采用改良的心律失常评分标准，能够对受试药物的抗心律失常疗效进行定量评估，还能揭示这些物质的致心律失常特性。这种改进的方法可方便地用于定量筛选受试药物的抗心律失常或致心律失常特性。