Bottasso O, Puig N, Amerio N, Morini J C
División Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Med Cutan Ibero Lat Am. 1988;16(5):397-401.
T cells and the theophylline resistant cells (the-r, helper cells) in peripheral blood of patients with different forms of leprosy were studied. Active lepromatous patients (LL+) showed a significant decrease in T lymphocytes and the-r cells. Nevertheless, in LL+ developing a reactional episode of erythema nodosum (LL-ENL) a restoration in the level of the-r cells was observed. It is concluded that in LL+ patients the depression of T cells and the-r cells represents an imbalance in the T-T cellular cooperation with a defective cellular immune response. On the other hand, the recovery of the-r cells in LL-ENL support the hypothesis of a cell mediated immune mechanism in the immunopathology of this reactional episode.
对不同类型麻风病患者外周血中的T细胞及茶碱抵抗细胞（the-r，辅助细胞）进行了研究。活动性瘤型麻风患者（LL+）的T淋巴细胞和the-r细胞显著减少。然而，在发生结节性红斑反应期的LL+患者（LL-ENL）中，观察到the-r细胞水平有所恢复。得出的结论是，在LL+患者中，T细胞和the-r细胞的减少代表了T细胞间合作的失衡以及细胞免疫反应存在缺陷。另一方面，LL-ENL中the-r细胞的恢复支持了在这一反应期免疫病理学中细胞介导免疫机制的假说。
