Musolino A, Soria V, Munari C, Devaux B, Merienne L, Constans J P, Chodkiewicz J P
Service de Neurochirugie, Centre Hospitalier Sainte-Anne, Paris.
Neurochirurgie. 1988;34(6):361-73.
During the period January 1975-October 1987, we performed stereotactic ventriculocisternostomy (V.C.S.) on 23 patients (13 M., 10 F.; age: 11-73 years, m: 33). Sometimes used as an isolated therapeutic procedure, V.C.S. may also follow stereotactic biopsies using Talairach's methodology. Serial stereotactic biopsies were performed in 15 out of 23 patients showing 11 tumoral lesion, two arachnoïdal cysts and two cryptic vascular malformations. Eight patients presented with an isolated aqueductal stenosis. Among the 12 non tumoral patients, seven had very large triventricular hydrocephalus (6 with a retroclival dilatation of the third ventricle) and 5 showed significant dilatation. Of the 11 tumoral patients, 7 had significant ventricular dilatation (1 with a protrusion of the floor of the third ventricle) and 4 with modest dilation. V.C.S. is done by creating an opening (diameter: 5-6 mm) in the floor of third ventricle with a fine forceps introduced through a tubular guide (diameter: 2.45 mm). The percutaneous double oblique transfrontal trajectory (drill-hole: 2.5 mm of diameter) passing through the foramina of Monro, avoids superficial and deep vessels visualised on the previous Stereoscopic Tele-Angiographic and Ventriculographic study. A systematic verification of the V.C.S. patency is made intraoperatively by injection of iodine contrast medium into the third ventricle.
(non tumoral patients: 12) (m follow-up: 4 years): two patients needed a ventricular shunt after 3 and 1 months respectively, the first one because of an associated communicant hydrocephalus, the second because of a post-operative meningeal infection. Long-term clinical and CT-Scan follow-up showed that complete resolution (7 cases) or partial (2 cases) improvement of symptoms and signs was not accompanied by normalization of ventricular size, even though the dilatation was significantly reduced in 8 cases and to a lesser extent in 2.
(tumoral patients: 11) (m follow-up: 3 years). Hydrocephalus was reduced in 6 cases and remained unchanged in 5. Two patients needed a ventricular shunt 2 years after the V.C.S.: 1 patient, because of a tumoral recurrence involving the region of the fenestration, the second patient because of adhesive arachnoiditis following reoperation for suspicion of recurrence, though this was found to be granulomatous inflammation. Two patients died as a result of their tumors at 2 and 6 years.
Stereotactic V.C.S. is the treatment of choice for triventricular obstructive hydrocephalus even when there is no retroclival dilatation of the floor of the third ventricle.
1975年1月至1987年10月期间,我们对23例患者(男13例,女10例;年龄11 - 73岁,平均33岁)实施了立体定向脑室脑池造瘘术(V.C.S.)。V.C.S.有时作为一种独立的治疗方法使用,也可在采用Talairach方法进行立体定向活检之后实施。23例患者中有15例进行了系列立体定向活检,发现11例肿瘤性病变、2例蛛网膜囊肿和2例隐匿性血管畸形。8例患者表现为单纯性导水管狭窄。在12例非肿瘤患者中,7例有非常大的三脑室脑积水(6例伴有三脑室斜坡后扩张),5例有明显扩张。11例肿瘤患者中,7例有明显脑室扩张(1例伴有三脑室底突出),4例扩张程度较轻。V.C.S.通过经直径2.45mm的管状导向器插入精细镊子在三脑室底部开口(直径:5 - 6mm)来完成。经Monro孔的经皮双斜额部轨迹(钻孔直径:2.5mm)可避免在之前的立体定向远距血管造影和脑室造影研究中显示的浅表和深部血管。术中通过向三脑室内注入碘造影剂对V.C.S.的通畅性进行系统验证。
(非肿瘤患者:12例)(平均随访4年):2例患者分别在3个月和1个月后需要脑室分流,第一例是因为合并交通性脑积水,第二例是因为术后脑膜感染。长期临床和CT扫描随访显示,症状和体征完全缓解(7例)或部分改善(2例),但脑室大小并未恢复正常,尽管8例患者的扩张明显减轻,2例患者减轻程度较小。
(肿瘤患者:11例)(平均随访3年)。6例患者脑积水减轻,5例患者脑积水保持不变。2例患者在V.C.S.术后2年需要脑室分流:1例患者是因为肿瘤复发累及造瘘区域,第二例患者是因为再次手术怀疑复发后出现粘连性蛛网膜炎,尽管后来发现是肉芽肿性炎症。2例患者分别在2年和6年因肿瘤死亡。
立体定向V.C.S.是三脑室梗阻性脑积水的首选治疗方法,即使三脑室底部没有斜坡后扩张。