Department of Reproductive and Menopausal Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Big Data Centre for Integrative Analysis, Gunma University Initiative for Advanced Research, Maebashi, Japan.
Maturitas. 2019 Mar;121:41-47. doi: 10.1016/j.maturitas.2018.12.010. Epub 2018 Dec 20.
Results of studies on the associations of soy food intake with urinary estrogen levels in premenopausal women and in postmenopausal women have been inconsistent. We examined the associations of urinary isoflavone levels as well as soy food intake with estrone (E1) and estradiol (E2) in pre- and postmenopausal women. In addition, we compared the levels of isoflavones, E1 and E2 across current hormone users such as those receiving hormone replacement therapy and those using oral contraceptives and non-users among both pre- and postmenopausal women. Urinary levels of isoflavones, E1 and E2 in 498 women (36 hormone users and 462 non-users) were analyzed. Premenopausal women with a higher frequency of soy food intake had higher urinary isoflavone levels, but there were no significant associations between E1 and E2 levels and urinary isoflavone levels. Levels of E1 and E2 in hormone users were significantly lower than those in hormone non-users among premenopausal women, but levels of E1 and E2 in hormone users were significantly higher than those in hormone non-users among postmenopausal women. Postmenopausal women with a higher frequency of soy food intake had higher urinary isoflavone levels, and postmenopausal women with high urinary isoflavone levels had significantly higher E1 and E2 levels. In conclusion, the associations of urinary isoflavone levels with urinary estrogen levels differed with menopausal status. Urinary levels of E1 and E2 were high in postmenopausal women with high urinary isoflavone levels but not in premenopausal women with high urinary isoflavone levels.
关于大豆食品摄入量与绝经前和绝经后妇女尿雌激素水平之间关联的研究结果并不一致。我们研究了尿异黄酮水平以及大豆食品摄入量与雌酮（E1）和雌二醇（E2）在绝经前和绝经后妇女中的相关性。此外，我们比较了绝经前和绝经后妇女中当前激素使用者（如接受激素替代疗法和使用口服避孕药者）和非使用者的异黄酮、E1 和 E2 水平。分析了 498 名妇女（36 名激素使用者和 462 名非使用者）的尿异黄酮、E1 和 E2 水平。大豆食品摄入量较高的绝经前妇女尿异黄酮水平较高，但 E1 和 E2 水平与尿异黄酮水平之间无显著相关性。与绝经前妇女中的非激素使用者相比，激素使用者的 E1 和 E2 水平明显较低，但与绝经后妇女中的非激素使用者相比，激素使用者的 E1 和 E2 水平明显较高。大豆食品摄入量较高的绝经后妇女尿异黄酮水平较高，且高尿异黄酮水平的绝经后妇女 E1 和 E2 水平显著较高。总之，尿异黄酮水平与尿雌激素水平的相关性因绝经状态而异。在高尿异黄酮水平的绝经后妇女中，E1 和 E2 水平较高，但在高尿异黄酮水平的绝经前妇女中则不然。
