饮食失调的遗传学：临床医生需要了解的内容。
Genetics of Eating Disorders: What the Clinician Needs to Know.
作者信息
Bulik Cynthia M, Blake Lauren, Austin Jehannine
机构信息
Department of Psychiatry, UNC Chapel Hill, University of North Carolina, CB 7160, Chapel Hill, NC 27599, USA; Department of Nutrition, University of North Carolina, CB 7400, Chapel Hill, NC 27599, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.
Department of Human Genetics, University of Chicago, Cummings Life Science Center, 920 East 58th Street, Chicago, IL 60637, USA.
出版信息
Psychiatr Clin North Am. 2019 Mar;42(1):59-73. doi: 10.1016/j.psc.2018.10.007.
Anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED) are heritable conditions that are influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) of AN have identified specific genetic loci implicated in AN, and genetic correlations have implicated both psychiatric and metabolic factors in its origin. No GWAS have been performed for BN or BED. Genetic counseling is an important tool and can aid families and patients in understanding risk for these illnesses.
神经性厌食症（AN）、神经性贪食症（BN）和暴饮暴食症（BED）是受遗传和环境因素影响的遗传性疾病。最近对神经性厌食症的全基因组关联研究（GWAS）已经确定了与神经性厌食症相关的特定基因位点，并且遗传相关性表明其发病起源涉及精神和代谢因素。尚未对神经性贪食症或暴饮暴食症进行全基因组关联研究。遗传咨询是一项重要工具，有助于家庭和患者了解这些疾病的风险。
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