Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
UK National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK.
Int J Eat Disord. 2021 May;54(5):785-793. doi: 10.1002/eat.23481. Epub 2021 Feb 28.
Genome-wide association studies have identified multiple genomic regions associated with anorexia nervosa. No genome-wide studies of other eating disorders, such as bulimia nervosa and binge-eating disorder, have been performed, despite their substantial heritability. Exploratively, we aimed to identify traits that are genetically associated with binge-type eating disorders.
We calculated genome-wide polygenic scores for 269 trait and disease outcomes using PRSice v2.2 and their association with anorexia nervosa, bulimia nervosa, and binge-eating disorder in up to 640 cases and 17,050 controls from the UK Biobank. Significant associations were tested for replication in the Avon Longitudinal Study of Parents and Children (up to 217 cases and 3,018 controls).
Individuals with binge-type eating disorders had higher polygenic scores than controls for other psychiatric disorders, including depression, schizophrenia, and attention deficit hyperactivity disorder, and higher polygenic scores for body mass index.
Our findings replicate some of the known comorbidities of eating disorders on a genomic level and motivate a deeper investigation of shared and unique genomic factors across the three primary eating disorders.
全基因组关联研究已经确定了多个与神经性厌食症相关的基因组区域。尽管暴食症和暴食障碍等其他饮食失调症具有相当大的遗传性，但尚未对其进行全基因组研究。本研究旨在探索与暴食症相关的遗传特征。
我们使用 PRSice v2.2 计算了 269 种特质和疾病结果的全基因组多基因评分，并将其与英国生物库中多达 640 例神经性厌食症、暴食症和暴食障碍病例和 17050 例对照进行关联分析。在雅芳纵向父母和儿童研究（多达 217 例病例和 3018 例对照）中对显著关联进行了复制检验。
与对照组相比，暴食症患者的其他精神障碍，包括抑郁症、精神分裂症和注意缺陷多动障碍的多基因评分更高，体重指数的多基因评分也更高。
我们的研究结果在基因组水平上复制了一些已知的饮食失调症的共病现象，并促使我们更深入地研究三种主要饮食失调症之间的共同和独特的基因组因素。
