衰老、MicroRNAs 与心力衰竭。
Aging, MicroRNAs, and Heart Failure.
出版信息
Curr Probl Cardiol. 2020 Dec;45(12):100406. doi: 10.1016/j.cpcardiol.2018.12.003. Epub 2018 Dec 29.
Abstract
Aging is a major risk factor for heart failure, one of the leading causes of death in Western society. The mechanisms that underlie the different forms of heart failure have been elucidated only in part and the role of noncoding RNAs is still poorly characterized. Specifically, microRNAs (miRNAs), a class of small noncoding RNAs that can modulate gene expression at the posttranscriptional level in all cells, including myocardial and vascular cells, have been shown to play a role in heart failure with reduced ejection fraction. In contrast, miRNAs role in heart failure with preserved ejection fraction, the predominant form of heart failure in the elderly, is still unknown. In this review, we will focus on age-dependent miRNAs in heart failure and on some other conditions that are prevalent in the elderly and are frequently associated with heart failure with preserved ejection fraction.
摘要
衰老是心力衰竭的一个主要危险因素，心力衰竭是西方社会主要的死亡原因之一。导致心力衰竭的不同形式的机制仅部分阐明，非编码 RNA 的作用仍知之甚少。具体来说，microRNAs（miRNAs）是一类小的非编码 RNA，可以在包括心肌细胞和血管细胞在内的所有细胞中在转录后水平调节基因表达，已被证明在射血分数降低性心力衰竭中发挥作用。相比之下，miRNAs 在射血分数保留性心力衰竭中的作用仍不清楚，射血分数保留性心力衰竭是老年人中主要的心力衰竭形式。在这篇综述中，我们将重点介绍与心力衰竭相关的依赖年龄的 miRNAs，以及一些在老年人中常见且常与射血分数保留性心力衰竭相关的其他疾病。
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