JAK/STAT 蛋白及其对 NK 细胞发育和功能的生物学影响。
JAK/STAT proteins and their biological impact on NK cell development and function.
机构信息
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Center for Human Immunobiology, Department of Allergy, Immunology and Rheumatology, Houston, TX, USA.
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Center for Human Immunobiology, Department of Allergy, Immunology and Rheumatology, Houston, TX, USA.
出版信息
Mol Immunol. 2019 Nov;115:21-30. doi: 10.1016/j.molimm.2018.12.005. Epub 2019 Jan 28.
NK cells are important early effectors in the innate immune response to a variety of viral infections and for elimination of tumor cells. The JAK/STAT signaling cascade is critical for NK cell development, maturation, survival, and proliferation, therefore, it is important to understand the role of this pathway in NK cell biology. Many cytokines can activate multiple JAK/STAT protein family members, creating a severe phenotype when mutations impair their function or expression. Here we discuss the impact of defective JAK/STAT signaling pathways on NK cell development, activation and cytotoxicity.
自然杀伤 (NK) 细胞是固有免疫反应的重要早期效应因子，可用于多种病毒感染和肿瘤细胞的清除。JAK/STAT 信号通路对于 NK 细胞的发育、成熟、存活和增殖至关重要，因此，了解该通路在 NK 细胞生物学中的作用非常重要。许多细胞因子可以激活多个 JAK/STAT 蛋白家族成员，当突变损害其功能或表达时，会产生严重的表型。在这里，我们讨论了缺陷 JAK/STAT 信号通路对 NK 细胞发育、激活和细胞毒性的影响。
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