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Role of factor VIII-binding capacity of endogenous von Willebrand factor in the development of factor VIII inhibitors in patients with severe hemophilia A.

作者信息

Repessé Yohann, Costa Catherine, Palla Roberta, Moshai Elika Farrokhi, Borel-Derlon Annie, D'Oiron Roseline, Rothschild Chantal, El-Beshlawy Amal, Elalfy Mohsen, Ramanan Vijay, Eshghi Peyman, Oldenburg Johannes, Pavlova Anna, Rosendaal Frits R, Peyvandi Flora, Kaveri Srinivas V, Lacroix-Desmazes Sébastien

机构信息

CHU de Caen, Hematology Laboratory, Caen, France.

INSERM, U1237, GIP Cyceron, Caen, France.

出版信息

Haematologica. 2019 Aug;104(8):e369-e372. doi: 10.3324/haematol.2018.212001. Epub 2019 Jan 31.

Abstract
摘要

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本文引用的文献

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A factor VIII-nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation.
Blood. 2018 Sep 13;132(11):1193-1197. doi: 10.1182/blood-2018-01-829523. Epub 2018 Jul 31.
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Biological considerations of plasma-derived and recombinant factor VIII immunogenicity.
Blood. 2017 Jun 15;129(24):3147-3154. doi: 10.1182/blood-2016-11-750885. Epub 2017 Apr 21.
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The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.
Haematologica. 2017 Feb;102(2):271-281. doi: 10.3324/haematol.2016.148502. Epub 2016 Oct 6.
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A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.
N Engl J Med. 2016 May 26;374(21):2054-64. doi: 10.1056/NEJMoa1516437.
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Dissecting intensive treatment as risk factor for inhibitor development in haemophilia.
Haemophilia. 2016 May;22(3):e241-4. doi: 10.1111/hae.12944. Epub 2016 Apr 14.
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The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.
Blood. 2013 Feb 21;121(8):1446-54. doi: 10.1182/blood-2012-06-434803. Epub 2012 Dec 6.
10
A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.
Blood. 2012 Sep 20;120(12):2512-20. doi: 10.1182/blood-2012-02-412361. Epub 2012 Jul 31.

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