De Gobbi Alberto, Mangano Mario Salvatore, Cova Giandavide, Lamon Claudio, Maccatrozzo Luigino
U.O.C. Urologia, Ulss 2 Marca Trevigiana, Ospedale Treviso, Treviso, Italy.
Urologia. 2019 May;86(2):96-98. doi: 10.1177/0391560318818951. Epub 2019 Feb 1.
Renal cell carcinoma has extremely heterogeneous presentation at the diagnosis: it may present as a confined organ disease, locally advanced, metastatic to locoregional lymph nodes or with single or multiple systemic metastases. Since chemotherapy and radiation therapy have not demonstrated efficacy either in primary therapy or in neo-adjuvant or adjuvant therapy for renal clear cell carcinoma, targeted agents like tirosine kinase inhibitors were developed and are largely used in locally advanced and metastatic renal cell carcinoma. Here, we present a rare case of ipsilateral renal cell carcinoma testicle metastasis, after radical nephrectomy and during tyrosine kinase inhibitors therapy. In addition, a retrospective search in PubMed, ScienceDirect, and Web of Science database on testicular metasteses from renal cell carcinoma under tyrosine kinase inhibitors therapy was performed.
它可能表现为局限性器官疾病、局部晚期、转移至局部区域淋巴结或伴有单个或多个全身转移。由于化疗和放疗在肾透明细胞癌的初始治疗、新辅助治疗或辅助治疗中均未显示出疗效，因此开发了酪氨酸激酶抑制剂等靶向药物，并广泛应用于局部晚期和转移性肾细胞癌。在此，我们报告一例罕见的同侧肾细胞癌睾丸转移病例，该病例发生在根治性肾切除术后且处于酪氨酸激酶抑制剂治疗期间。此外，我们还在PubMed、ScienceDirect和Web of Science数据库中对接受酪氨酸激酶抑制剂治疗的肾细胞癌睾丸转移情况进行了回顾性检索。
