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[淀粉样变性的肾脏方面]

[Nephrologic aspects of amyloidosis].

作者信息

Maduell F, Diez J, Idoate M, Pardo-Mindán F J, Purroy A

机构信息

Servicio de Nefrología, Facultad de Medicina, Universidad de Navarra, Pamplona.

出版信息

Rev Med Univ Navarra. 1988 Jul-Sep;32(3):153-7.

PMID:3070686
Abstract

Amyloidosis is a syndrome characterized by intercellular deposition of a predominantly proteic substance in any organ and tissue. The kidney is one of the most affected organs and very important in as much as its involvements might produce the initial manifestations of the syndrome and could be the one responsible to establish the prognosis in many cases. In this paper, the most relevant features of the different types of renal amyloidosis (glomerular, vascular and tubulo-interstitial), and one special type of amyloidosis in patients on chronic hemodialysis and likewise other interesting aspects in the evolution of amyloidosis of kidney transplanted patients were reviewed. Emphasis was placed on renal vascular amyloidosis and on amyloidosis among patients on hemodialysis as these might deserve special clinical and etiopathogenic considerations according to our own experience.

摘要

淀粉样变性是一种综合征,其特征为在任何器官和组织中细胞间沉积主要为蛋白质的物质。肾脏是受影响最严重的器官之一,并且非常重要,因为肾脏受累可能会产生该综合征的初始表现,而且在许多情况下可能是决定预后的因素。本文综述了不同类型肾淀粉样变性(肾小球性、血管性和肾小管间质性)的最相关特征,以及慢性血液透析患者的一种特殊类型淀粉样变性,同样也回顾了肾移植患者淀粉样变性演变过程中的其他有趣方面。重点关注肾血管淀粉样变性以及血液透析患者中的淀粉样变性,因为根据我们自己的经验,这些可能值得特别的临床和病因学考虑。

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