Tobler A
Medizinische Universitätsklinik, Inselspital, Bern.
Schweiz Med Wochenschr. 1988 Oct 15;118(41):1463-7.
1,25-dihydroxyvitamin D3 (1.25[OH]2D3), the most active metabolite of vitamin D3, plays an important role in bone and mineral metabolism. There is growing evidence that the vitamin D endocrine system may be important in other systems as well: 1,25(OH)2D3 is synthesized in extrarenal tissue. Macrophages from both normal human individuals and patients with sarcoidosis are capable of producing 1,25(OH)2D3. Specific receptors for 1,25(OH)2D3 are present in a number of cells and tissues other than those of the classical target organs (bone, intestine and kidney). The possible role of 1,25(OH)2D3 in both the modulation of immune responses and normal and leukemic hematopoiesis is discussed.
1,25 - 二羟维生素D3（1,25[OH]2D3）是维生素D3最具活性的代谢产物，在骨骼和矿物质代谢中发挥重要作用。越来越多的证据表明，维生素D内分泌系统在其他系统中可能也很重要：1,25(OH)2D3在肾外组织中合成。正常人和结节病患者的巨噬细胞都能够产生1,25(OH)2D3。除了经典靶器官（骨骼、肠道和肾脏）的细胞和组织外，许多其他细胞和组织中也存在1,25(OH)2D3的特异性受体。本文讨论了1,25(OH)2D3在免疫反应调节以及正常和白血病造血过程中的可能作用。
