Utah Center for Nanomedicine , Nano Institute of Utah , 36 South Wasatch Drive , Salt Lake City , Utah 84112 , United States.
Bioconjug Chem. 2019 Feb 20;30(2):384-399. doi: 10.1021/acs.bioconjchem.8b00853. Epub 2019 Feb 1.
Polymeric matrices inherently protect viral vectors from pre-existing immune conditions, limit dissemination to off-target sites, and can sustain vector release. Advancing methodologies in development of particulate based vehicles have led to improved encapsulation of viral vectors. Polymeric delivery systems have contributed to increasing cellular transduction, responsive release mechanisms, cellular infiltration, and cellular signaling. Synthetic polymers are easily customizable, and are capable of balancing matrix retention with cellular infiltration. Natural polymers contain inherent biorecognizable motifs adding therapeutic efficacy to the incorporated viral vector. Recombinant polymers use highly conserved motifs to carefully engineer matrices, allowing for precise design including elements of vector retention and responsive release mechanisms. Composite polymer systems provide opportunities to create matrices with unique properties. Carefully designed matrices can control spatiotemporal release patterns that synergize with approaches in regenerative medicine and antitumor therapies.
聚合物基质从固有保护病毒载体免受现有免疫条件的影响，限制其向非靶标部位的扩散，并能维持载体的释放。基于颗粒的载体的开发方法的进步导致了对病毒载体的更好的包封。聚合物递药系统有助于提高细胞转导、响应性释放机制、细胞浸润和细胞信号传导。合成聚合物易于定制，并能够平衡基质保留与细胞浸润。天然聚合物含有固有的生物可识别基序，为所包含的病毒载体增加治疗效果。重组聚合物使用高度保守的基序来精心设计基质，允许进行精确的设计，包括载体保留和响应性释放机制的元素。复合聚合物系统为创造具有独特性能的基质提供了机会。精心设计的基质可以控制时空释放模式，与再生医学和抗肿瘤治疗方法协同作用。
