镉导致牛蛙（牛蛙）外皮电阻降低。

Cadmium-induced decrease in the outer facing skin resistance of a bullfrog (Rana catesbeiana).

作者信息

Hayashi H, Takada M, Arita A

出版信息

Jpn J Physiol. 1978;28(1):63-73. doi: 10.2170/jjphysiol.28.63.

DOI:10.2170/jjphysiol.28.63

Abstract

Effects of cadmium on the electrical properties of frog skin were investigated by using the microelectrode technique. The epidermal application of 2 mM Cd for 5 min increased both the short circuit current and the skin potential, and decreased the skin resistance (RM). Cadmium also decreased intracellular potential with reference to the epidermal solution (PDi) and the electrical resistance between the epidermal solution and the tip of a microelectrode (RM1) located in the stratum germinativum. deltaRM that is RM,Cd-RM, control seemed to approximately coincide with deltaRM1 which is RM1,Cd-RM1,control. Comparing with our previous results, i.e., Cd decreased RNa (the resistance to the active Na current) and increased Rsigma (the resistance to the passive ions) but did not altered ENa (the electromotive force of active Na current) in the later stage (15 min or later). Cd seemed to decrease the RNa component at the epidermal side of the skin in the early stage (less than 5 min).

摘要

采用微电极技术研究了镉对蛙皮电特性的影响。在表皮施加2 mM镉5分钟后，短路电流和皮肤电位均升高，皮肤电阻（RM）降低。相对于表皮溶液（PDi）以及位于生发层的微电极尖端与表皮溶液之间的电阻（RM1），镉还降低了细胞内电位。镉处理后的RM（RM,Cd）与对照RM（RM,control）的差值deltaRM似乎与镉处理后的RM1（RM1,Cd）与对照RM1（RM1,control）的差值deltaRM1大致相符。与我们之前的结果相比，即在后期（15分钟及以后）镉降低了RNa（对主动钠电流的电阻）并增加了Rsigma（对被动离子的电阻），但未改变ENa（主动钠电流的电动势）。在早期（少于5分钟），镉似乎降低了皮肤表皮侧的RNa成分。