5-HTTLPR 和 COMT Val158Met 与述情障碍无关：新证据和荟萃分析。

5-HTTLPR and COMT Val158Met are not associated with alexithymia: New evidence and meta-analyses.

机构信息

College of Life Science, Northwest University, Xi'an 710069, China.

Institute of Population and Health, Northwest University, Xi'an 710069, China.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:263-270. doi: 10.1016/j.pnpbp.2019.01.015. Epub 2019 Jan 29.

DOI:10.1016/j.pnpbp.2019.01.015

PMID:30707988

Abstract

BACKGROUNDS

Alexithymia refers to the difficulties in identifying and describing one's own emotions, lacking of imagination, and an externally oriented thinking style. Studies up to date have examined the associations of 5-HTTLPR and COMT Val158Met polymorphisms with alexithymia. However, the previous findings were mixed.

METHODS

We replicated the associations by scoring on alexithymia with the 20-item Toronto Alexithymia Scale and genotyping the polymorphisms of 5-HTTLPR and COMT Val158Met in a large population of college students (N = 1698). Moreover, we also meta-analyzed the associations with five samples (N = 7517) for the 5-HTTLPR and with five samples (N = 2186) for the COMT Val158Met.

RESULTS

Neither the replicated study nor the meta-analyses indicated the 5-HTTLPR and COMT Val158Met were associated with alexithymia.

CONCLUSIONS

The findings suggest that the 5-HTTLPR and COMT Val158Met polymorphisms are not associated with alexithymia. However, genetic-environmental studies with different ethnicity and psychopathology should be carried in future.

摘要

背景

述情障碍是指识别和描述自身情绪的困难、缺乏想象力以及外向型思维方式。迄今为止的研究已经检验了 5-HTTLPR 和 COMT Val158Met 多态性与述情障碍的关联。然而，先前的研究结果存在差异。

方法

我们通过使用 20 项多伦多述情障碍量表对述情障碍进行评分，并对大量大学生（N=1698）的 5-HTTLPR 和 COMT Val158Met 多态性进行基因分型，对关联进行了复制。此外，我们还对 5-HTTLPR 的五个样本（N=7517）和 COMT Val158Met 的五个样本（N=2186）进行了荟萃分析。