ITAB Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, 66100, Chieti, Italy.
ITAB Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, 66100, Chieti, Italy.
Neuroimage. 2019 Apr 1;189:589-600. doi: 10.1016/j.neuroimage.2019.01.071. Epub 2019 Jan 30.
Neurobiological research has classically focused on perceptual decision-making, although many real-life decisions are based on information that is not currently available but stored in long-term memory. Previous studies have suggested that the lateral parietal cortex encodes decision-related signals during item recognition judgments. In the present fMRI study, we employed a parametric manipulation of evidence for source memory judgments and tested several hypotheses concerning memory decision signals in parietal cortex. As expected, the mean BOLD signal in several parietal regions was modulated by decision evidence. An analysis of the locally distributed pattern of activity, moreover, identified a parietal cluster showing significant choice-predictive activity even at the lowest level of decision evidence, with decoding accuracy that increased as a function of evidence. Decoding patterns were consistent across subjects as shown by a leave-one-subject-out classification analysis. Finally, we found that the pattern of choice-predictive activity in parietal lobe was temporally correlated with that observed in medial temporal regions traditionally associated with long-term memory functions. The present findings are consistent with a general role of lateral parietal regions located around the intraparietal sulcus in representing a decision variable for memory-based decisions.
神经生物学研究一直专注于感知决策，尽管许多现实生活中的决策都是基于当前不可用但存储在长期记忆中的信息。先前的研究表明，外侧顶叶皮层在项目识别判断过程中编码与决策相关的信号。在本 fMRI 研究中，我们采用了源记忆判断的参数操作，并测试了几个关于顶叶皮层记忆决策信号的假设。正如预期的那样，几个顶叶区域的平均 BOLD 信号被决策证据所调节。此外，对活动局部分布模式的分析确定了一个顶叶簇，即使在最低的决策证据水平下，也显示出显著的选择预测活动，并且随着证据的增加，解码准确性也会增加。通过一项排除一个被试的分类分析，证明了解码模式在被试之间是一致的。最后，我们发现，顶叶叶与传统上与长期记忆功能相关的内侧颞叶区域观察到的选择预测活动在时间上是相关的。这些发现与外侧顶叶区域在基于记忆的决策中表示决策变量的一般作用一致。
