Du Jialin, Zhu Yu, Zhao Chengtian, Yang Dongju, Yu Tao, Zhang Xiaohua, Ren Liankun, Wang Yuping
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Hum Neurosci. 2022 May 6;16:836374. doi: 10.3389/fnhum.2022.836374. eCollection 2022.
It is a fundamental ability to discriminate incongruent information in daily activity. However, the underlying neural dynamics are still unclear. Using stereoelectroencephalography (SEEG), in this study, we investigated the fine-grained and different states of incongruent information processing in patients with refractory epilepsy who underwent intracranial electrode implantation. All patients performed a delayed match-to-sample paradigm in the sequential pairs of visual stimuli (S1 followed by S2). Participants were asked to discriminate whether the relevant feature of S2 was identical to S1 while ignoring the irrelevant feature. The spatiotemporal cortical responses evoked by different conditions were calculated and compared, respectively, in the context of brain intrinsic functional networks. In total, we obtained SEEG recordings from 241 contacts in gray matter. In the processing of irrelevant incongruent information, the activated brain areas included the superior parietal lobule, supramarginal gyrus, angular gyrus, inferior temporal gyrus, and fusiform gyrus. By comparing the relevant incongruent condition with the congruent condition, the activated brain areas included the middle frontal gyrus, superior temporal gyrus, middle temporal gyrus, posterior superior temporal sulcus, and posterior cingulate cortex. We demonstrated the dynamics of incongruent information processing with high spatiotemporal resolution and suggested that the process of automatic detection of irrelevant incongruent information requires the involvement of local regions and relatively few networks. Meanwhile, controlled discrimination of relevant incongruent information requires the participation of extensive regions and a wide range of nodes in the network. Furthermore, both the frontoparietal control network and default mode network were engaged in the incongruent information processing.
在日常活动中辨别不一致信息是一项基本能力。然而，其潜在的神经动力学仍不清楚。在本研究中，我们使用立体脑电图（SEEG），对接受颅内电极植入的难治性癫痫患者不一致信息处理的细粒度和不同状态进行了研究。所有患者在连续的视觉刺激对（S1后跟S2）中执行延迟匹配样本范式。要求参与者辨别S2的相关特征是否与S1相同，同时忽略不相关特征。在脑内在功能网络的背景下，分别计算和比较了不同条件下诱发的时空皮质反应。我们总共从241个灰质触点获得了SEEG记录。在处理不相关的不一致信息时，激活的脑区包括顶上小叶、缘上回、角回、颞下回和梭状回。通过将相关不一致条件与一致条件进行比较，激活的脑区包括额中回、颞上回、颞中回、颞上沟后部和后扣带回皮质。我们以高时空分辨率展示了不一致信息处理的动态过程，并表明自动检测不相关不一致信息的过程需要局部区域和相对较少的网络参与。同时，对相关不一致信息的控制性辨别需要广泛区域和网络中广泛节点的参与。此外，额顶控制网络和默认模式网络都参与了不一致信息处理。
