细胞学与芯针活检在间叶组织肿瘤诊断中的实际应用

Practical Application of Cytology and Core Biopsy in the Diagnosis of Mesenchymal Tumors.

作者信息

Papke David J, Jo Vickie Y

机构信息

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Surg Pathol Clin. 2019 Mar;12(1):227-248. doi: 10.1016/j.path.2018.11.002.

DOI:10.1016/j.path.2018.11.002

PMID:30709446

Abstract

Soft tissue neoplasms are increasingly being sampled by core needle biopsy and fine-needle aspiration (FNA), and these small biopsy specimens pose unique diagnostic challenges. Many advances in ancillary testing enable detection of characteristic immunophenotypes and molecular alterations, allowing accurate classification of soft tissue tumors in these small biopsy samples. This review outlines pattern-based diagnostic approaches to core biopsies and FNAs of soft tissue neoplasms, including formulation of practical differential diagnoses and relevant application of ancillary tests.

摘要

软组织肿瘤越来越多地通过粗针活检和细针穿刺抽吸（FNA）进行取样，而这些小活检标本带来了独特的诊断挑战。辅助检测的许多进展能够检测到特征性免疫表型和分子改变，从而在这些小活检样本中对软组织肿瘤进行准确分类。本综述概述了基于模式的软组织肿瘤粗针活检和FNA诊断方法，包括制定实用的鉴别诊断以及辅助检测的相关应用。