Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2020 Jan;119(1 Pt 1):157-163. doi: 10.1016/j.jfma.2019.01.010. Epub 2019 Jan 29.
BACKGROUND/PURPOSE: The irradiation of 660-nm light-emitting diodes (LEDs) has exhibited potential to accelerate oral wound healing and prevent periodontal breakdown in rodents. This study was to evaluate the clinical effectiveness of 660-nm LEDs during non-surgical periodontal therapy (NSPT).
Nineteen patients with at least one periodontitis-involved tooth in three quadrants received NSPT, and three protocols of LED light irradiation, including LED light irradiation from initial clinical assessment (T0) until the completion of scaling and root planning (T1) (LED01), LED light irradiation from T1 until re-evaluation (T2) (LED02), and no LED light irradiation (control treatment), were randomly assigned to respective quadrant. Clinical parameters were assessed at T0 and T2, and such biomarkers as IL-1β and MMP-8 from gingival crevicular fluid were assessed at T0, T1, and T2.
At T2, all examined sites exhibited significantly reduced probing pocket depth (PD), clinical attachment level (CAL), gingival bleeding index, plaque score, and visual analog scale. In the sites with greatest initial PD and CAL, LED01 and LED02 significantly reduced PD and CAL compared with the control treatment. IL-1β and MMP-8 were reduced in all groups at T1 and T2, and the reduction of MMP-8 was the most notable in LED01.
LED light irradiation during or after scaling and root planing assisted in the recovery of periodontium and can be used as an adjunct treatment during NSPT, specifically for sites with severe periodontal breakdown.
背景/目的：660nm 发光二极管（LED）的辐照已显示出加速口腔伤口愈合和预防啮齿动物牙周破坏的潜力。本研究旨在评估 660nm LED 在非手术性牙周治疗（NSPT）中的临床效果。
19 名患者至少有一颗牙周炎受累牙在三个象限接受 NSPT，以及三种 LED 光照射方案，包括从初始临床评估（T0）到洁治和根面平整完成（T1）的 LED 光照射（LED01），从 T1 到重新评估（T2）的 LED 光照射（LED02），以及无 LED 光照射（对照治疗），随机分配到相应的象限。在 T0 和 T2 评估临床参数，并在 T0、T1 和 T2 评估龈沟液中的 IL-1β 和 MMP-8 等生物标志物。
在 T2 时，所有检查部位的探诊袋深度（PD）、临床附着水平（CAL）、牙龈出血指数、菌斑评分和视觉模拟评分均显著降低。在初始 PD 和 CAL 最大的部位，LED01 和 LED02 与对照治疗相比，PD 和 CAL 显著降低。在所有组中，IL-1β 和 MMP-8 在 T1 和 T2 时均降低，MMP-8 的降低在 LED01 中最为明显。
在洁治和根面平整期间或之后进行 LED 光照射有助于牙周组织的恢复，可以作为 NSPT 的辅助治疗方法，特别是对于牙周破坏严重的部位。
