Buhles N, Altmeyer P
Dermatologische Klinik, Ruhr-Universität Bochum im St. Josef-Hospital.
Z Hautkr. 1988 Nov 15;63(11):926-34.
In vivo ultrasound examination has been introduced into dermatology as a non-invasive diagnostic technique. The resolution capacity, however, has been limited so far, and the in vivo ultrasonic features have not been fully understood. Using high frequencies (GHz range) in acoustic microscopy, we have been able to achieve a resolution comparable to that in light microscopy. In a first step, we examined normal human skin sections and compared them to histological specimens. The following study on melanocytic nevi, malignant melanoma, and metastases of melanoma showed that their acoustic images were more pronounced than those of the surrounding tissue. The echo intensity of solid basal cell carcinoma and squamous cell carcinoma resembled that of the epithelium. The structures found in acoustic microscopy can be correlated to those seen in light microscopy.
体内超声检查已作为一种非侵入性诊断技术引入皮肤科。然而，到目前为止其分辨率能力有限，而且体内超声特征尚未被完全理解。通过在声学显微镜中使用高频（吉赫兹范围），我们已经能够实现与光学显微镜相当的分辨率。第一步，我们检查了正常人体皮肤切片并将它们与组织学标本进行比较。接下来对黑素细胞痣、恶性黑色素瘤和黑色素瘤转移灶的研究表明，它们的声学图像比周围组织的更明显。实性基底细胞癌和鳞状细胞癌的回声强度与上皮组织的相似。在声学显微镜中发现的结构可以与光学显微镜中看到的结构相关联。
