立体定向体部放射治疗后肝癌的影像学反应:典型影像学表现及误区。

Imaging post-stereotactic body radiation therapy responses for hepatocellular carcinoma: typical imaging patterns and pitfalls.

机构信息

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 585 University Avenue, Toronto, ON, M5G 2N2, Canada.

Laboratory Medicine Program, Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada.

出版信息

Abdom Radiol (NY). 2019 May;44(5):1795-1807. doi: 10.1007/s00261-019-01901-y.

Abstract

Stereotactic body radiation therapy (SBRT) has increased utility in the management of hepatocellular carcinoma (HCC) ranging from local therapy in early-stage HCC not suitable for other focal therapies to end-stage HCC. As the indications for the use of SBRT in HCC expand, diagnostic imaging is being increasingly used to assess response to treatment. The imaging features of tumor response do not parallel those of other focal therapies such as radiofrequency ablation or trans-arterial chemoembolization that immediately devascularize the tumor. The tumor response to SBRT on imaging takes much longer and often shows gradual changes including the reduction of enhancement and size over several months. It is essential to recognize the typical imaging patterns of response, as well as the appearance of focal liver reaction in the non-target liver that can confound image interpretation. The timing of treatment response assessment imaging is fundamental to minimize the potential for false negative response. The purpose of this article is to review the variable post-SBRT imaging features of HCC and adjacent liver parenchyma and discuss the potential pitfalls of imaging evaluation after SBRT for HCC.

摘要

立体定向体部放射治疗(SBRT)在肝癌(HCC)的治疗中应用越来越广泛,从不适合其他局部治疗的早期 HCC 的局部治疗到晚期 HCC。随着 SBRT 在 HCC 中的应用指征的扩大,诊断性影像学检查越来越多地用于评估治疗反应。肿瘤反应的影像学特征与其他局部治疗方法(如射频消融或经动脉化疗栓塞)不同,后者会立即使肿瘤血管化。SBRT 对肿瘤的反应在影像学上需要更长的时间,通常表现为数月内逐渐变化,包括增强和大小的减少。因此,识别典型的反应影像学模式以及非靶肝中局灶性肝反应的出现至关重要,因为这些可能会混淆图像解释。评估治疗反应影像学的时机对于最小化潜在的假阴性反应非常重要。本文的目的是回顾 HCC 和相邻肝实质的 SBRT 后可变影像学特征,并讨论 HCC 后 SBRT 影像学评估的潜在陷阱。

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