Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan.
Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, Kyoto, 610-0394, Japan.
Neurochem Int. 2019 May;125:67-73. doi: 10.1016/j.neuint.2019.01.024. Epub 2019 Jan 30.
The neostriatum has a mosaic organization consisting of striosome and matrix compartments. It receives glutamatergic excitatory afferents from the cerebral cortex and thalamus. Recent behavioral studies in rats revealed a selectively active medial prefronto-striosomal circuit during cost-benefit decision-making. However, clarifying the input/output organization of striatal compartments has been difficult because of its complex structure. We recently demonstrated that the source of thalamostriatal projections are highly organized in striatal compartments. This finding indicated that the functional properties of striatal compartments are influenced by their cortical and thalamic afferents, presumably with different time latencies. In addition, these afferents likely support the unique dynamics of striosome and matrix compartments. In this manuscript, we review the anatomy of basal ganglia networks with regard to striosome/matrix structure. We place specific focus on thalamostriatal projections at the population and single neuron level.
新纹状体具有由纹状体和基质隔室组成的镶嵌组织。它接收来自大脑皮层和丘脑的谷氨酸能兴奋性传入。最近对大鼠的行为研究表明，在成本效益决策过程中，内侧前额叶-纹状体隔室回路选择性地活跃。然而，由于其复杂的结构，阐明纹状体隔室的输入/输出组织一直很困难。我们最近表明，丘脑纹状体投射的来源在纹状体隔室中高度组织化。这一发现表明，纹状体隔室的功能特性受到其皮质和丘脑传入的影响，可能具有不同的时间延迟。此外，这些传入可能支持纹状体和基质隔室的独特动力学。在本文中，我们回顾了基底神经节网络的解剖结构，特别是纹状体/基质结构。我们特别关注群体和单个神经元水平的丘脑纹状体投射。
