Ozek Erdinc, Akdag Halil, Tosuner Zeynep, Abdallah Anas, Hatiboglu Mustafa Aziz
Neurosurgery Department, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Clin Neurol Neurosurg. 2019 Mar;178:46-50. doi: 10.1016/j.clineuro.2019.01.016. Epub 2019 Jan 25.
To assess the correlation between PHH-3 and STAT-3 in grade I and grade II meningiomas.
Medical records were retrospectively reviewed for all cranial cases which diagnosed and underwent surgery at Bezmialem Vakif University Hospital between 2012 and 2017. All cranial grade I and grade II meningioma patients constituted the core sample for this study.
This series included 104 (69 female, 35 male) patients, with a median age of 57.3 years. The mean preoperative course was 23.0 ± 40.5 months. The most common symptom was headache (76%) and followed by seizure (24%), weakness (18%) and visual disturbances (14%). Seventy one (68.2%) patients were diagnosed as WHO grade I meningioma and 33 (31.8%) were WHO grade II, grade III meningiomas were excluded from study due to small number of patients. Subtypes of meningioma includes 5 angiomatous (4,8%), 6 fibroblastic (5.7%), 1 meningothelial (0,9%), 11 psammomatous (10,5%), 3 secretory (2,8%), 43 transitional (41,3%) and 33 atypical (31,7%) meningiomas. There is a strong correlation with PHH-3 and Ki-67 (p:0,001>) and mitosis index (p:0,001 > ) although there is no correlation with STAT-3 (p:0,260). There is a strong correlation with STAT-3 and Ki-67 (p:0,013), although there is no correlation with mitosis index (p:0,085) and PHH-3 (p:0,260).
In our study we also obtain same results with Ki-67 and mitotic index, although correlation with PHH-3 and STAT-3 is firstly determined and there was no statistically significant relation were observed. Depends on the STAT-3 cell proliferation feature, inactivation of these pathways may predict new chemotherapies for grade II meningiomas.
评估PHH-3与STAT-3在I级和II级脑膜瘤中的相关性。
回顾性分析2012年至2017年间在贝兹米阿勒姆瓦基夫大学医院诊断并接受手术的所有颅脑病例的病历。所有I级和II级颅脑脑膜瘤患者构成本研究的核心样本。
该系列包括104例患者（69例女性，35例男性），中位年龄为57.3岁。术前平均病程为23.0±40.5个月。最常见的症状是头痛（76%），其次是癫痫发作（24%）、无力（18%）和视觉障碍（14%）。71例（68.2%）患者被诊断为WHO I级脑膜瘤，33例（31.8%）为WHO II级，III级脑膜瘤因患者数量少而被排除在研究之外。脑膜瘤亚型包括5例血管瘤型（4.8%）、6例纤维型（5.7%）、1例脑膜内皮型（0.9%）、11例砂粒体型（10.5%）、3例分泌型（2.8%）、43例过渡型（41.3%）和33例非典型型（31.7%）脑膜瘤。PHH-3与Ki-67（p：0.001>）和有丝分裂指数（p：0.001>）有很强的相关性，尽管与STAT-3无相关性（p：0.260）。STAT-3与Ki-67有很强的相关性（p：0.013），尽管与有丝分裂指数（p：0.085）和PHH-3无相关性（p：0.260）。
在我们的研究中，尽管首次确定了与PHH-3和STAT-3的相关性，但未观察到统计学上的显著关系，我们在Ki-67和有丝分裂指数方面也得到了相同的结果。根据STAT-3细胞增殖特征，这些通路的失活可能为II级脑膜瘤预测新的化疗方法。
