Dyatlov Alexander V, Apt Alexander S, Linge Irina A
Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia.
Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia; Department of Immunology, School of Biology, M. V. Lomonosov Moscow State University, Russia.
Tuberculosis (Edinb). 2019 Jan;114:1-8. doi: 10.1016/j.tube.2018.10.011. Epub 2018 Oct 28.
The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.
B细胞和抗体在结核病免疫、保护及发病机制中的作用仍存在矛盾之处。肺组织中靠近活动性结核病灶处存在有组织的B细胞滤泡，这引发了关于这些细胞在局部宿主-病原体相互作用中作用的疑问。在这篇简短的综述中，我们总结了关于驻留在结核性肺中的B细胞表型、它们的分泌活性、与其他免疫细胞的相互作用以及在结核保护性免疫与致病性免疫中可能参与情况的知识现状。
