高危子宫内膜癌的主动脉旁淋巴结转移：FDG PET-CT的表现

Para-aortic Lymph Node Invasion in High-risk Endometrial Cancer: Performance of FDG PET-CT.

作者信息

Legros Maxime, Margueritte François, Tardieu Antoine, Deluche Elise, Mbou Valere Belle, Lacorre Aymeline, Ceuca Alexandru, Aubard Yves, Monteil Jacques, Sallee Camille, Gauthier Tristan

机构信息

Department of Gynecology and Obstetrics, University Hospital Center of Limoges, Limoges, France

Department of Gynecology and Obstetrics, University Hospital Center of Limoges, Limoges, France.

出版信息

Anticancer Res. 2019 Feb;39(2):619-625. doi: 10.21873/anticanres.13155.

DOI:10.21873/anticanres.13155

PMID:30711937

Abstract

AIM

F-Fluorodeoxyglucose positron-emission tomography integrated with computed tomography (FDG PET-CT) is a non-invasive examination that could be helpful for the management of endometrial cancer. This study investigated the performance of FDG PET-CT in assessing para-aortic (PA) lymph-node involvement in high-risk endometrial cancer.

MATERIALS AND METHODS

This was a retrospective, single-center study carried out between 2009 and 2018. The inclusion criteria were high-risk and locally advanced type 1 or 2 endometrial cancer with FDG PET-CT before PA lymphadenectomy.

RESULTS

During the study period, among 142 patients with high-risk endometrial cancer, 35 patients (24.6%) underwent FDG PET-CT followed by PA lymphadenectomy. In 25% of cases, PA lymphadenectomy was not performed due to the discovery of metastasis. FDG PET-CT had a sensitivity of 50%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 75%, accuracy of 80% and an area under the curve of 0.75 for the evaluation of PA involvement.

CONCLUSION

According to its high specificity in PA lymph-node evaluation, a positive PET scan might allow PA lymphadenectomy to be avoided.

摘要

目的

氟脱氧葡萄糖正电子发射断层扫描与计算机断层扫描相结合（FDG PET-CT）是一种非侵入性检查，有助于子宫内膜癌的管理。本研究调查了FDG PET-CT在评估高危子宫内膜癌腹主动脉旁（PA）淋巴结受累情况方面的表现。

材料与方法

这是一项于2009年至2018年进行的回顾性单中心研究。纳入标准为高危且局部晚期的1型或2型子宫内膜癌，在进行PA淋巴结清扫术前接受FDG PET-CT检查。

结果

在研究期间，142例高危子宫内膜癌患者中，35例（24.6%）接受了FDG PET-CT检查，随后进行了PA淋巴结清扫术。在25%的病例中，由于发现转移而未进行PA淋巴结清扫术。FDG PET-CT评估PA受累的敏感性为50%，特异性为100%，阳性预测值为100%，阴性预测值为75%，准确率为80%，曲线下面积为0.75。