Kumagai-Togashi Arisa, Uozaki Hiroshi, Kikuchi Yoshinao, Watabe Shiori, Numakura Satoe, Watanabe Masato
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan
Anticancer Res. 2019 Feb;39(2):635-640. doi: 10.21873/anticanres.13157.
BACKGROUND/AIM: CD10 function in urothelial carcinoma (UC) remains controversial. We previously reported that miR-21 in UC may be a prognostic marker for cancer progression. The aim of this study was to examine the clinicopathological significance of CD10 expression in UC and its relationship with miR-21 expression.
Immunohistochemistry for CD10 was performed on 232 UCs. CD10 expression in TCs and stroma was evaluated respectively, and its association with carcinogenesis and survival was analyzed.
High tumorous CD10 was significantly associated with higher tumor stage, histological grade and vessel infiltration, and poorer prognosis, whereas stromal CD10 was significantly associated with younger age, higher tumor stage, and vessel infiltration. On multivariable analysis, CD10 expression in TCs, miR-21 expression in TCs and TS, and tumor stage were independent prognostic factors.
Tumorous CD10 is more strongly related to progression of UC than stromal CD10 and is an independent factor for UC prognosis.
背景/目的：CD10在尿路上皮癌（UC）中的作用仍存在争议。我们之前报道过，UC中的miR-21可能是癌症进展的一个预后标志物。本研究的目的是探讨CD10表达在UC中的临床病理意义及其与miR-21表达的关系。
对232例UC进行CD10免疫组织化学检测。分别评估肿瘤细胞（TCs）和基质中CD10的表达，并分析其与肿瘤发生及生存的关系。
肿瘤组织中高表达CD10与更高的肿瘤分期、组织学分级和血管浸润显著相关，且预后较差，而基质中CD10与较年轻的年龄、更高的肿瘤分期和血管浸润显著相关。多变量分析显示，肿瘤细胞中的CD10表达、肿瘤细胞和肿瘤基质中的miR-21表达以及肿瘤分期是独立的预后因素。
肿瘤组织中的CD10比基质中的CD10与UC进展的关系更密切，并且是UC预后的一个独立因素。
