肝内胆管癌患者肝切除术后F-氟脱氧葡萄糖正电子发射断层扫描代谢参数的影响

Impact of Metabolic Parameters of F-Fluorodeoxyglucose Positron-emission Tomography After Hepatic Resection in Patients With Intrahepatic Cholangiocarcinoma.

作者信息

Harimoto Norifumi, Hoshino Kouki, Muranushi Ryo, Hagiwara Kei, Yamanaka Takahiro, Ishii Norihiro, Tsukagoshi Mariko, Igarashi Takamichi, Tanaka Hiroshi, Watanabe Akira, Kubo Norio, Araki Kenichirou, Tomonaga Hiroyasu, Higuchi Tetsuya, Tsushima Yoshito, Shirabe Ken

机构信息

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan.

出版信息

Anticancer Res. 2019 Feb;39(2):971-977. doi: 10.21873/anticanres.13201.

DOI:10.21873/anticanres.13201

PMID:30711983

Abstract

BACKGROUND

The aim of this study was to identify the prognostic impact of metabolic parameters of F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) in patients with intrahepatic cholangiocarcinoma (IHCC) undergoing hepatic resection.

PATIENTS AND METHODS

Twenty-four patients with IHCC who underwent surgical resection were enrolled and F-FDG PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured, as well as overall and recurrence-free survival.

RESULTS

High TLG was significantly associated with large tumor size and high carbohydrate antigen 19-9 level. Patients with high SUVmax, high MTV or high TLG had a significantly worse prognosis regarding both overall and recurrence-free survival than those with low SUVmax, low MTV and low TLG, respectively. Multivariate Cox proportional hazards analysis identified that high TLG significantly influenced both overall and recurrence-free survival.