Harimoto Norifumi, Hoshino Kouki, Muranushi Ryo, Hagiwara Kei, Yamanaka Takahiro, Ishii Norihiro, Tsukagoshi Mariko, Igarashi Takamichi, Tanaka Hiroshi, Watanabe Akira, Kubo Norio, Araki Kenichirou, Tomonaga Hiroyasu, Higuchi Tetsuya, Tsushima Yoshito, Shirabe Ken
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan.
Anticancer Res. 2019 Feb;39(2):971-977. doi: 10.21873/anticanres.13201.
The aim of this study was to identify the prognostic impact of metabolic parameters of F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) in patients with intrahepatic cholangiocarcinoma (IHCC) undergoing hepatic resection.
Twenty-four patients with IHCC who underwent surgical resection were enrolled and F-FDG PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured, as well as overall and recurrence-free survival.
High TLG was significantly associated with large tumor size and high carbohydrate antigen 19-9 level. Patients with high SUVmax, high MTV or high TLG had a significantly worse prognosis regarding both overall and recurrence-free survival than those with low SUVmax, low MTV and low TLG, respectively. Multivariate Cox proportional hazards analysis identified that high TLG significantly influenced both overall and recurrence-free survival.
Preoperative assessment of TLG by F-FDG PET might be a useful prognostic predictor after hepatic resection in patients with IHCC.
本研究旨在确定氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）的代谢参数对接受肝切除的肝内胆管癌（IHCC）患者预后的影响。
纳入24例行手术切除的IHCC患者，测量F-FDG PET参数最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病灶糖酵解（TLG），以及总生存期和无复发生存期。
高TLG与肿瘤体积大及糖类抗原19-9水平高显著相关。SUVmax高、MTV高或TLG高的患者在总生存期和无复发生存期方面分别比SUVmax低、MTV低和TLG低的患者预后明显更差。多因素Cox比例风险分析表明，高TLG对总生存期和无复发生存期均有显著影响。
FDG PET术前评估TLG可能是IHCC患者肝切除术后有用的预后预测指标。
