Silén Suvi, Haapaniemi Aaro, Dickinson Amy, Rönn Karin, Mäkitie Antti
a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
b Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences , Intervention and Technology, Karolinska Institutet, Karolinska University Hospital , Stockholm , Sweden.
Acta Otolaryngol. 2019 Jan;139(1):85-89. doi: 10.1080/00016489.2018.1527037. Epub 2019 Feb 3.
Laryngeal squamous cell carcinoma (LSCC) is rare in the young.
We characterized the clinical behavior of LSCC and assessed the presentation of second primary tumors (SPCs) in this patient population.
Data from the Finnish Cancer Registry (FCR) were used to identify an epidemiological series of LSCC patients diagnosed at the age of 40 years or under, during 1953-2012 in Finland. Data regarding primary treatment, survival, and SPCs were available. To further characterize the comorbidity and lifestyle factors of young patients with LSCC, institutional data were collected of patients treated at the Helsinki University Hospital during 1967-2012.
We identified 151 patients, with a mean follow-up of 252 months. The 10-year overall survival (OS) was 75% and the disease-specific survival was 84%. SPCs were diagnosed in 26% (n = 39), with a median delay of 28 years. Of the 35 patients in the institutional series from Helsinki, 22 (63%) were current or former smokers. LSCC recurred in 28% of patients.
The delay to SPCs in young patients was significantly longer compared with the general LSCC population. As factors underlying this phenomenon cannot be identified by this retrospective study, further studies are warranted.
喉鳞状细胞癌（LSCC）在年轻人中较为罕见。
我们对LSCC的临床行为进行了特征描述，并评估了该患者群体中第二原发性肿瘤（SPC）的表现。
利用芬兰癌症登记处（FCR）的数据，确定了1953 - 2012年期间在芬兰诊断出的40岁及以下LSCC患者的流行病学系列。可获得有关初次治疗、生存情况和SPC的数据。为了进一步描述年轻LSCC患者的合并症和生活方式因素，收集了1967 - 2012年期间在赫尔辛基大学医院接受治疗的患者的机构数据。
我们确定了151例患者，平均随访252个月。10年总生存率（OS）为75%，疾病特异性生存率为84%。26%（n = 39）的患者被诊断出患有SPC，中位延迟时间为28年。在赫尔辛基机构系列中的35例患者中，22例（63%）为现吸烟者或既往吸烟者。28%的患者LSCC复发。
与一般LSCC人群相比，年轻患者发生SPC的延迟时间明显更长。由于这项回顾性研究无法确定这一现象的潜在因素，因此有必要进行进一步研究。
