Department of Breast Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai, P.R. China.
Shanghai University of Medicine and Health Sciences, Shanghai, P.R. China.
Rejuvenation Res. 2019 Dec;22(6):498-502. doi: 10.1089/rej.2018.2154. Epub 2019 Mar 22.
In recent years, the clinical application of circulating tumor cell (CTCs) detection has become one of the research hotspots in the field of precision medicine. CTCs detection is noninvasive, easy to obtain, can be repeatedly collected, and highly repeatable with other advantages. It not only can be a real-time comprehensive monitoring of cancer treatment but also can have a large number of applications, including early diagnosis of tumor, timely evaluation of efficacy, condition monitoring, resistance factor analysis, prognosis judgment, individualized treatment of tumors, drug guidance, and so on. At present, many large-scale clinical studies at home and abroad run through all stages of breast cancer diagnosis and treatment. For different treatment stages of breast cancer, the application value of CTCs detection is different. Compared with traditional detection methods, CTCs have advantages in dynamic monitoring of disease changes and efficacy evaluation in real-time. In the era of breast cancer classificational and individualized treatment, CTCs detection can provide patients with the most timely and optimized treatment plan.
近年来，循环肿瘤细胞（CTC）检测的临床应用已成为精准医学领域的研究热点之一。CTC 检测具有非侵入性、易于获取、可重复采集、与其他方法高度重复等优点。它不仅可以实时全面监测癌症治疗，而且具有广泛的应用，包括肿瘤的早期诊断、疗效的及时评估、病情监测、耐药因素分析、预后判断、肿瘤的个体化治疗、药物指导等。目前，国内外许多大型临床研究贯穿乳腺癌诊治的各个阶段。对于不同治疗阶段的乳腺癌，CTC 检测的应用价值不同。与传统检测方法相比，CTC 在实时动态监测疾病变化和疗效评估方面具有优势。在乳腺癌分类和个体化治疗时代，CTC 检测可以为患者提供最及时和优化的治疗方案。
