Gasparin A A, Pamplona Bueno de Andrade N, Hax V, Tres G Leví, Veronese F V, Monticielo O A
Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Lupus. 2019 Mar;28(3):265-272. doi: 10.1177/0961203319826695. Epub 2019 Feb 2.
Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predict disease activity and renal histology, but also lead to earlier treatment. In previous studies, the soluble vascular cell adhesion molecule-1 measured in urine showed a strong association with the presence of lupus nephritis, with clinical and histological activity indexes of the disease and with more severe renal lesions. This paper reviews the main urinary biomarkers of lupus nephritis that have been studied, with special emphasis on vascular cell adhesion molecule-1 results.
肾脏受累是系统性红斑狼疮的主要并发症之一，对患者的发病率和死亡率有重大影响。肾活检仍是诊断的金标准，但存在诸多局限性。从这个意义上讲，最近的几项研究旨在识别不仅能预测疾病活动和肾脏组织学，还能实现早期治疗的生物标志物。在以往研究中，尿液中检测到的可溶性血管细胞黏附分子-1与狼疮性肾炎的存在、疾病的临床和组织学活动指标以及更严重的肾脏病变密切相关。本文综述了已研究的狼疮性肾炎主要尿液生物标志物，特别强调了血管细胞黏附分子-1的研究结果。
