Wang J M, Chen Z G, Colotta F, Mantovani A
Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Behring Inst Mitt. 1988 Aug(83):270-3.
Recombinant GM-CSF induced migration across polycarbonate filters of monocytes and polymorphonuclear leukocytes. Checkerboard analysis revealed that induction of phagocyte migration involved actual chemotaxis. Hence GM-CSF, released by activated endothelium and leukocytes, may play a role in phagocyte recruitment to amplify resistance against noxious agents. Activation of leukocytes by GM-CSF was associated with early, transient augmentation of the expression of the c-fos protooncogene. c-fos expression may be associated with functional reprogramming of phagocytes by this cytokine.
重组粒细胞-巨噬细胞集落刺激因子（GM-CSF）诱导单核细胞和多形核白细胞穿过聚碳酸酯滤膜迁移。棋盘分析表明，吞噬细胞迁移的诱导涉及实际的趋化作用。因此，由活化的内皮细胞和白细胞释放的GM-CSF可能在吞噬细胞募集中发挥作用，以增强对有害物质的抵抗力。GM-CSF对白细胞的激活与原癌基因c-fos表达的早期短暂增强有关。c-fos表达可能与该细胞因子对吞噬细胞的功能重编程有关。
