Highlight report: Necrosis-apoptosis conundrum of hepatocytes: mode of hepatocyte death after acetaminophen intoxication.
作者信息
Ghallab Ahmed
机构信息
Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
出版信息
EXCLI J. 2018 Dec 19;17:1191-1193. doi: 10.17179/excli2018-2013. eCollection 2018.
Abstract
摘要
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本文引用的文献
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Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.大鼠在体和原代肝细胞肝毒物毒理学基因组目录。
Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.
2
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.Mito-tempo 可预防急性肝损伤，但在对乙酰氨基酚肝毒性的晚期阶段会引起有限的继发性细胞凋亡。
Arch Toxicol. 2019 Jan;93(1):163-178. doi: 10.1007/s00204-018-2331-8. Epub 2018 Oct 15.
3
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.原代人肝细胞细胞毒性试验中潜伏期的相关性。
Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.
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Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.利用 MALDI MSI 对乙酰氨基酚及其代谢物和加合物在小鼠肝脏中的分布进行时空可视化。
Arch Toxicol. 2018 Sep;92(9):2963-2977. doi: 10.1007/s00204-018-2271-3. Epub 2018 Jul 23.
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Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.基于组学的博森坦诱导人肝癌 HepaRG 细胞培养物的反应。
Arch Toxicol. 2018 Jun;92(6):1939-1952. doi: 10.1007/s00204-018-2214-z. Epub 2018 May 14.
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Highlight report: Metabolomics in hepatotoxicity testing.重点报告：代谢组学在肝毒性测试中的应用
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Highlight report: The pseudolobule in liver fibrosis.重点报告：肝纤维化中的假小叶。
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Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19.
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Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.基于生理学的小鼠模型研究表明，在肝毒性损伤后，清除能力的损失加剧。
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