Pennar Amy, Naar Sylvie, Woods Steven, Nichols Sharon, Outlaw Angulique, Ellis Deborah
a Center for Translational Behavioral Science , Florida State University , Tallahassee , FL , USA.
b Department of Psychology , University of Houston , Houston , TX , USA.
AIDS Care. 2018;30(sup4):59-64. doi: 10.1080/09540121.2019.1576851. Epub 2019 Feb 3.
Using a phased model of intervention development, we developed an intervention to promote resilience in youth living with HIV via improved neurocognitive resources. First, youth completed a naturalistic prospective memory (PM) task and were randomized into a visualization condition or control condition. Next, 47 of these participants completed another naturalistic PM task and were randomized into Calendaring condition, an Alarm condition, a Combined condition, or a Control condition. Youth with low PM demonstrated observable gains from the visualization technique. Youth in the Combined Calendaring and Alarm condition demonstrated significantly better performance than participants in the Control and Calendaring conditions. In a Proof-of-Concept study with 16 youth, the previous findings were translated into a single session in-person intervention followed by tailored text messaging to improve adherence and viral load via improved neurocognitive resources. The resulting intervention showed a signal of effect with viral load reductions in youth with available data. Targeting compensatory strategies to enhance neurocognitive functioning may promote resilience and health outcomes. A randomized pilot study with a control condition is the next step.
我们采用分阶段的干预开发模型，通过改善神经认知资源，开发了一种促进感染艾滋病毒青年恢复力的干预措施。首先，青年完成一项自然主义前瞻性记忆（PM）任务，并被随机分为可视化组或对照组。接下来，这些参与者中的47人完成另一项自然主义PM任务，并被随机分为日历组、闹钟组、组合组或对照组。PM水平较低的青年通过可视化技术表现出明显的进步。日历和闹钟组合组的青年表现明显优于对照组和日历组的参与者。在一项针对16名青年的概念验证研究中，先前的研究结果被转化为一次面对面的干预，随后进行量身定制的短信提醒，以通过改善神经认知资源来提高依从性和降低病毒载量。在有可用数据的青年中，最终的干预措施显示出病毒载量降低的效果信号。针对补偿策略以增强神经认知功能可能会促进恢复力和健康结果。下一步是进行一项有对照组的随机试点研究。
