Pathirana Dilan, Johnston Barbara, Johnston Peter
a School of Natural Sciences and Queensland Micro- and Nanotechnology Centre, Griffith University , Nathan 4111 , Australia.
Comput Methods Biomech Biomed Engin. 2019 Apr;22(5):475-489. doi: 10.1080/10255842.2018.1564821. Epub 2019 Feb 4.
Coarctation of the Aorta is a congenital narrowing of the aorta and diagnosis can be difficult. Treatments result in idiopathic sequelae including hypertension. Untreated patients are known to develop increased arterial stiffness in the upper body, which worsens with time. We present results from simulations with a one-dimensional mathematical model, about the effect of stiffness, stenting, surgery and coarctation severity on blood pressure, Pulsatility and Resistivity Index. One conclusion is that increased stiffness may explain both hypertension in treated patients and why diagnosis can be difficult.
主动脉缩窄是一种先天性的主动脉狭窄，诊断可能会很困难。治疗会导致包括高血压在内的特发性后遗症。已知未经治疗的患者上半身动脉僵硬度会增加，且会随着时间恶化。我们展示了一维数学模型模拟的结果，内容涉及僵硬度、支架植入、手术以及缩窄严重程度对血压、搏动性和阻力指数的影响。一个结论是，僵硬度增加可能既解释了接受治疗患者的高血压问题，也解释了诊断困难的原因。
