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探索基于RNA干扰技术的植物育种创新的专利格局。

Exploring the Patent Landscape of RNAi-based Innovation for Plant Breeding.

作者信息

Frisio Dario Gianfranco, Ventura Vera

机构信息

Department of Environmental Science and Policy, Università degli Studi di Milano, Milano, Italy.

出版信息

Recent Pat Biotechnol. 2019;13(3):207-216. doi: 10.2174/1872208313666190204121109.

Abstract

BACKGROUND

RNA interference (RNAi) is an innovative technique for plant improvement based on naturally occurring mechanisms which show great potential because of their high specificity and possibility to be applied through innovative methods of topical application in plants. This specific innovation sector is worth analysing from the economic perspective given the great potentiality of RNAi-based plants and products to support modern agriculture in reaching the goals for the improvement of agri-food chains global sustainability. This paper aims to evaluate the global landscape of RNAi innovation by analysing patent data as indicators of innovation output.

METHODS

We revised all patents relating to RNAi in plants based on a dataset of roughly seven thousand patent families. The analysis classified inventions according to a set of variables able to characterise the dynamics of innovation (i.e. public/private ownership, type of plants involved, main traits) while the use of concentration indices provided insights into the evolution of this sector.

RESULTS

Results revealed that RNAi is a technique with promising future applications, able to provide solutions to a great variety of agricultural issues and principally developed by the US and Chinese applicants, whereas European innovation capacity in this field appears to be limited.

CONCLUSION

The innovation landscape of plant breeding is rapidly evolving and RNAi technique is probably going to play a major role in this field.

摘要

背景

RNA干扰(RNAi)是一种基于自然发生机制的植物改良创新技术,因其高度特异性以及可通过植物局部施用的创新方法应用的可能性而具有巨大潜力。鉴于基于RNAi的植物和产品在支持现代农业实现农业食品链全球可持续性改善目标方面具有巨大潜力,从经济角度分析这一特定创新领域很有必要。本文旨在通过分析专利数据作为创新产出指标来评估RNAi创新的全球格局。

方法

我们基于约七千个专利族的数据集,对所有与植物RNAi相关的专利进行了修订。分析根据一组能够表征创新动态的变量(即公共/私人所有权、所涉及的植物类型、主要性状)对发明进行分类,同时使用集中度指数深入了解该领域的发展。

结果

结果表明,RNAi是一种具有广阔未来应用前景的技术,能够为各种各样的农业问题提供解决方案,主要由美国和中国的申请人开发,而欧洲在该领域的创新能力似乎有限。

结论

植物育种的创新格局正在迅速演变,RNAi技术可能会在该领域发挥重要作用。

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