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Bone mineral density in osteoporotic patients with pyogenic vertebral osteomyelitis: effect of early versus late treatment for osteoporosis.骨质疏松性化脓性脊柱骨髓炎患者的骨密度：早期与晚期治疗骨质疏松症的效果。
Osteoporos Int. 2018 Dec;29(12):2761-2770. doi: 10.1007/s00198-018-4695-2. Epub 2018 Sep 17.
2
Fracture Prediction With Modified-FRAX in Older HIV-Infected and Uninfected Men.使用改良FRAX对老年HIV感染和未感染男性进行骨折预测
J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):513-20. doi: 10.1097/QAI.0000000000000998.
3
Differential responses of osteoblasts and macrophages upon Staphylococcus aureus infection.金黄色葡萄球菌感染后成骨细胞和巨噬细胞的不同反应。
BMC Microbiol. 2014 Jul 25;14:207. doi: 10.1186/s12866-014-0207-5.
4
T cells from chronic bone infection show reduced proliferation and a high proportion of CD28⁻ CD4 T cells.慢性骨感染患者的 T 细胞增殖能力下降，且 CD28⁻ CD4 T 细胞比例较高。
Clin Exp Immunol. 2014 Apr;176(1):49-57. doi: 10.1111/cei.12245.
5
Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection.金黄色葡萄球菌蛋白 A 与成骨细胞肿瘤坏死因子受体 1 结合导致核因子 κB 的激活和骨感染中白细胞介素-6 的释放。
Microbiology (Reading). 2013 Jan;159(Pt 1):147-154. doi: 10.1099/mic.0.063016-0. Epub 2012 Nov 15.
6
Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis.儿童急性金黄色葡萄球菌骨髓炎的病理性骨折。
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Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection.关节炎、骨质疏松症、癌症和感染的骨免疫学研究进展。
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Increased risk of fragility fractures among HIV infected compared to uninfected male veterans.与未感染 HIV 的男性退伍军人相比，HIV 感染者发生脆性骨折的风险增加。
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Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis.近期发病的类风湿关节炎患者手部及全身骨密度的变化
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FRAX and the assessment of fracture probability in men and women from the UK.FRAX与英国男性和女性骨折概率评估
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老年男性骨髓炎患者脆性骨折发生率增加。

Increased Fragility Fracture Rates in Older Men With Osteomyelitis.

机构信息

Section of Rheumatology, Allergy and Clinical Immunology, Yale School of Medicine, New Haven.

Veteran Affairs (VA) Connecticut Healthcare System, West Haven.

出版信息

Clin Infect Dis. 2019 Sep 13;69(7):1239-1242. doi: 10.1093/cid/ciz077.

DOI:10.1093/cid/ciz077
PMID:30715288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6743834/
Abstract

In this study, we evaluated fracture incidence over a 10-year period among men with and without osteomyelitis from the Veterans Aging Cohort Study. Fracture incidence was significantly higher among those with osteomyelitis at all osteoporotic fracture sites after adjusting for key related risk factors. Future prospective studies are warranted.

摘要

在这项研究中，我们从退伍军人老龄化队列研究中评估了 10 年间有无骨髓炎男性的骨折发生率。在调整了关键相关风险因素后，所有骨质疏松性骨折部位的骨髓炎患者骨折发生率均显著更高。未来需要前瞻性研究。