Division of Antiviral Products, Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
J Infect Dis. 2020 Jan 2;221(2):214-217. doi: 10.1093/infdis/jiz037.
Using published data, we found a direct correlation between the incidence of rectal gonorrhea and human immunodeficiency virus (HIV) infection in men who have sex with men who were not using oral preexposure prophylaxis. HIV incidence was predicted using rectal gonorrhea incidence as the determinant in regression analysis. The observed correlation suggest that rectal gonorrhea incidence can potentially serve as a predictor of HIV incidence. If confirmed with additional data, a quantitative correlation for incidence of the 2 infections could be useful in active-controlled HIV prevention trials where low HIV incidence is expected. Widespread improvements in treatment as prevention and gonorrhea control can negatively impact the correlation and its utility.
利用已发表的数据，我们发现，对于未使用口腔暴露前预防（PrEP）的男男性行为者，直肠淋病的发病率与人类免疫缺陷病毒（HIV）感染之间存在直接相关性。在回归分析中，使用直肠淋病发病率作为决定因素来预测 HIV 发病率。观察到的相关性表明，直肠淋病发病率可能可以作为 HIV 发病率的预测指标。如果有更多数据证实，这两种感染的发病率的定量相关性可能对预期 HIV 发病率较低的主动对照 HIV 预防试验有用。治疗即预防和淋病控制的广泛改善可能会对相关性及其应用产生负面影响。
