Department of Neurosurgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
Department of Pediatric Neurology, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey.
World Neurosurg. 2019 May;125:e658-e664. doi: 10.1016/j.wneu.2019.01.144. Epub 2019 Feb 1.
The relationship between superior cervical ganglia (SCG) ischemia due to bilateral common carotid artery ligation (BCCAL) and basilar artery (BA) reconfiguration was investigated.
Twenty-three rabbits were randomly divided into 3 groups: group III rabbits underwent BCCAL (n = 13), group II rabbits were sham-operated controls (n = 5), and group I rabbits did not undergo surgery (n = 5). Degenerated neuron densities (DND) within the SCG were correlated with the BA vasodilatation index (VDI).
Mean live and DND in SCG of group I rabbits were 11.235 ± 982/μm and 11 ± 3/μm, respectively, with a mean heart rate of 294 ± 21 beats/min. Mean SCG DND and heart rates were 213 ± 42/μm and 242 ± 17 beats/min for the sham group (group II) rabbits and 1743 ± 285/μm and 199 ± 19 beats/min for the study group (group III) rabbits, respectively. The BA VDI values in the sham group (group II) (1.32 ± 0.10) and the study group (group III) (0.976 ± 0.112) significantly differed from those in the control group (group I) (1.65 ± 0.12; P < 0.005) versus the sham group (group II) (P < 0.0001) versus the BCCAL applied group (group III) and between group II and group III (P < 0.005).
A meaningful and paradoxic correlation was detected between the BA VDI values and degenerated neuron density of SCG after BCCAL. Although a low degenerated neuron density within SCG may provoke excessive sympathetic activity and prevent excessive BA dilatation with steno-occlusive carotid artery diseases, a high degenerated neuron density may cause dangerous vasodilatation of BA.
研究了由于双侧颈总动脉结扎（BCCAL）引起的颈上神经节（SCG）缺血与基底动脉（BA）重构之间的关系。
将 23 只兔子随机分为 3 组：BCCAL 组（n=13）、假手术对照组（n=5）和未手术组（n=5）。SCG 内变性神经元密度（DND）与 BA 血管扩张指数（VDI）相关。
未手术组（I 组）兔子的 SCG 活神经元和 DND 分别为 11.235±982/μm 和 11±3/μm，平均心率为 294±21 次/分。假手术组（II 组）兔子的 SCG DND 和心率分别为 213±42/μm 和 242±17 次/分，研究组（III 组）兔子的 DND 和心率分别为 1743±285/μm 和 199±19 次/分。假手术组（II 组）（1.32±0.10）和研究组（III 组）（0.976±0.112）的 BA VDI 值与对照组（I 组）（1.65±0.12）相比差异有统计学意义（P<0.005），与假手术组（II 组）相比差异有统计学意义（P<0.0001），与 BCCAL 组（III 组）相比差异有统计学意义，与 II 组和 III 组之间差异有统计学意义（P<0.005）。
BCCAL 后，BA VDI 值与 SCG 变性神经元密度之间存在有意义的矛盾关系。尽管 SCG 内低变性神经元密度可能引起过度的交感神经活动，并防止颈内动脉狭窄性疾病导致 BA 过度扩张，但高变性神经元密度可能导致 BA 危险的血管扩张。
