Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Medicine, Department of Diabetes and Nutrition, Cluj-Napoca, Romania.
Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Medicine, Department of the Internal Medicine, Cluj-Napoca, Romania.
Cytokine. 2019 Apr;116:134-138. doi: 10.1016/j.cyto.2019.01.006. Epub 2019 Feb 1.
Endothelial dysfunction is a common feature in hypertension and type 2 diabetes. Whether blood pressure (BP) variability is influencing serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) remains to be clarified. We aimed to assess the association between the circulating adhesion molecules and ambulatory blood pressure variability in patients with type 2 diabetes and controls.
The study included data from type 2 diabetes with controlled BP (n = 55), type 2 diabetes with uncontrolled BP (n = 55) and control subjects (n = 28). ICAM-1 and VCAM-1 were measured with specific enzyme-linked immunosorbent assay method. BP variability was assessed using standard deviation of mean systolic and diastolic BP evaluated during 24-hour ambulatory BP monitoring.
The uncontrolled BP type 2 diabetes group had significantly higher serum ICAM-1 and VCAM-1 levels compared to controlled BP type 2 diabetes and control groups. In linear regression analysis, after adjustment, higher ICAM-1 was consistently associated with higher daytime and 24-hour diastolic BP variability, and daytime systolic BP variability in the study population. VCAM-1 was associated only with daytime systolic BP variability.
Our study evaluating the association of serum ICAM-1 and VCAM-1 with 24-hour ambulatory BP variability in patients with type 2 diabetes and controls might offer better understanding of the mechanisms generating endothelial dysfunction. Elevated 24-hour ambulatory BP variability might induce endothelial activation by increasing circulating adhesion molecules levels.
内皮功能障碍是高血压和 2 型糖尿病的共同特征。血压变异性是否会影响血清细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）仍不清楚。我们旨在评估 2 型糖尿病患者和对照组中循环黏附分子与动态血压变异性之间的关系。
本研究纳入了血压控制良好的 2 型糖尿病患者（n=55）、血压控制不佳的 2 型糖尿病患者（n=55）和对照组患者（n=28）。采用特定的酶联免疫吸附测定法测量 ICAM-1 和 VCAM-1。使用标准偏差评估 24 小时动态血压监测期间的平均收缩压和舒张压变异性来评估血压变异性。
与血压控制良好的 2 型糖尿病组和对照组相比，血压控制不佳的 2 型糖尿病组的血清 ICAM-1 和 VCAM-1 水平显著升高。在线性回归分析中，经过调整后，较高的 ICAM-1 与研究人群中白天和 24 小时舒张压变异性以及白天收缩压变异性均呈正相关。VCAM-1 仅与白天收缩压变异性相关。
本研究评估了 2 型糖尿病患者和对照组中血清 ICAM-1 和 VCAM-1 与 24 小时动态血压变异性的关系，这可能有助于更好地了解产生内皮功能障碍的机制。升高的 24 小时动态血压变异性可能通过增加循环黏附分子水平而导致内皮激活。
