神经肽Y免疫反应性优先定位于大鼠腰段性二态核。

Neuropeptide Y immunoreactivity is preferentially located in rat lumbar sexually dimorphic nuclei.

作者信息

Newton B W, Hamill R W

机构信息

Neurology Unit, Monroe Community Hospital, University of Rochester, School of Medicine and Dentistry, NY 14603.

出版信息

Neurosci Lett. 1988 Nov 22;94(1-2):10-6. doi: 10.1016/0304-3940(88)90262-5.

DOI:10.1016/0304-3940(88)90262-5

PMID:3071746

Abstract

The distribution of neuropeptide Y-like immunoreactivity (NPY-LI) was examined in the ventral gray lumbar spinal cord of male and female rats. Fibers containing NPY-LI were distributed in a sexually dimorphic manner in three motor nuclei: the male cremaster nucleus (CN), spinal nucleus of the bulbocavernosus (SNB) and the dorsolateral nucleus, pars medialis (mDLN) receive a greater number of fibers with NPY-LI than females. Fibers with NPY-LI had the following ratios: males, mDLN greater than or equal to SNB greater than CN greater than dorsolateral nucleus, pars lateralis (1DLN) greater than remaining lumbar ventral gray horn motoneurons (VGH); females, mDLN greater than or equal to SNB greater than or equal to CN greater than VGH greater than or equal to 1DLN. In addition, a previously undescribed small column of motoneurons, located between mDLN and SNB, is outlined by fibers which contain NPY-LI in both sexes. The role of NPY in lumbar sexually dimorphic nuclei is presently unknown.

摘要

对雄性和雌性大鼠腰段脊髓腹侧灰质中神经肽Y样免疫反应性（NPY-LI）的分布进行了研究。含有NPY-LI的纤维在三个运动核中呈性别二态性分布：雄性提睾肌核（CN）、球海绵体肌脊髓核（SNB）和背外侧核内侧部（mDLN）比雌性接受更多含NPY-LI的纤维。含NPY-LI的纤维比例如下：雄性，mDLN≥SNB＞CN＞背外侧核外侧部（1DLN）＞其余腰段腹侧灰质角运动神经元（VGH）；雌性，mDLN≥SNB≥CN＞VGH≥1DLN。此外，在mDLN和SNB之间有一小群先前未描述的运动神经元，在两性中均由含NPY-LI的纤维勾勒出轮廓。目前尚不清楚NPY在腰段性别二态核中的作用。