发育过程中NMDA电流电压依赖性的变化。
Changes in voltage dependence of NMDA currents during development.
作者信息
Ben-Ari Y, Cherubini E, Krnjevic K
机构信息
INSERM U-29, Paris, France.
出版信息
Neurosci Lett. 1988 Nov 22;94(1-2):88-92. doi: 10.1016/0304-3940(88)90275-3.
N-Methyl-D-aspartate (NMDA), applied by superfusion to hippocampal slices evokes comparable peak inward currents in CA3 pyramidal cells of adult and 0-10 day-old rats. However, NMDA current-voltage plots from immature neurones do not consistently show the region of negative slope conductance characteristic of adult. Therefore at a critical stage of development, NMDA activation may elicit substantial inward currents and Ca2+ influx at resting membrane potential.
通过超灌流施加于海马切片的N-甲基-D-天冬氨酸（NMDA），在成年大鼠和0至10日龄大鼠的CA3锥体细胞中诱发相当的内向电流峰值。然而，来自未成熟神经元的NMDA电流-电压图并不一致地显示出成人大脑中特有的负斜率电导区域。因此，在发育的关键阶段，NMDA激活可能在静息膜电位下引发大量内向电流和Ca2+内流。
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