The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):236-243. doi: 10.1016/j.numecd.2018.12.003. Epub 2018 Dec 14.
Elevated resting heart rate (RHR) is associated with risk of type 2 diabetes mellitus (T2DM). However, the association of change in RHR (ΔRHR) and incident T2DM is not fully elucidated. We aimed to assess the dose-response association between 6-year ΔRHR and T2DM.
A total of 12155 non-T2DM participants ≥18 years old were enrolled during 2007-2008 and followed up during 2013-2014. ΔRHR was calculated by subtracting the baseline RHR from the RHR value at 6-year follow-up. Age-, sex-, and RHR-specific relative risks (RRs) and 95% confidence intervals (CIs) for the effect of ΔRHR on incident T2DM were calculated by using modified Poisson regression models. As compared with ΔRHR of 0 beats/min, the adjusted risk of T2DM was significantly increased with RHR increment and reduced with RHR reduction. ΔRHR was positively associated with future risk of T2DM [RR per unit increase: 1.03 (1.03-1.04)]. As compared with stable change in RHR group (-5<ΔRHR<5 beats/min), for ΔRHR ≤ -10 beats/min, -10<ΔRHR ≤ -5 beats/min, 5≤ΔRHR<10 beats/min, and ΔRHR ≥10 beats/min groups, the pooled adjusted RR (95% CI) of T2DM was 0.69 (0.55-0.86), 0.90 (0.73-1.11), 1.31 (1.07-1.61), and 1.90 (1.59-2.26), respectively. This significant association still existed on subgroup analyses based on age, sex, and baseline RHR and sensitivity analyses.
Dynamic RHR change was significantly associated with incident T2DM. Our study suggests that RHR may be a non-invasive clinical indicator for interventions aiming to reduce incident T2DM in the general population.
静息心率（RHR）升高与 2 型糖尿病（T2DM）风险相关。然而，RHR 的变化（ΔRHR）与 T2DM 事件之间的关联尚未完全阐明。本研究旨在评估 6 年ΔRHR 与 T2DM 之间的剂量-反应关系。
共纳入 12155 名年龄≥18 岁、无 T2DM 的参与者，于 2007-2008 年入组，于 2013-2014 年进行随访。ΔRHR 通过从 6 年随访时的 RHR 值中减去基线 RHR 计算得出。采用校正泊松回归模型，计算不同ΔRHR 与 T2DM 事件的年龄、性别和 RHR 特异的相对风险（RR）和 95%置信区间（CI）。与ΔRHR 为 0 相比，RHR 增加与 T2DM 风险增加相关，RHR 降低与 T2DM 风险降低相关。ΔRHR 与 T2DM 的发生风险呈正相关[每单位增加的 RR：1.03（1.03-1.04）]。与 RHR 稳定变化组（-5<ΔRHR<5 次/分）相比，ΔRHR≤-10 次/分、-10<ΔRHR≤-5 次/分、5<ΔRHR<10 次/分和ΔRHR≥10 次/分组的 T2DM 合并校正 RR（95%CI）分别为 0.69（0.55-0.86）、0.90（0.73-1.11）、1.31（1.07-1.61）和 1.90（1.59-2.26）。基于年龄、性别和基线 RHR 的亚组分析以及敏感性分析均显示出这种显著关联。
动态 RHR 变化与 T2DM 事件显著相关。本研究表明，RHR 可能是普通人群中降低 T2DM 事件发生风险的非侵入性临床指标。
