Howell C K, Jacob Jesse, Mok Steve
University of North Texas Health Science Center, Fort Worth, USA.
Medical City Dallas, TX, USA.
Hosp Pharm. 2019 Feb;54(1):51-56. doi: 10.1177/0018578718769240. Epub 2018 Apr 10.
The purpose of this study was to determine the time required for antimicrobial stewardship (AS) activities at a small community hospital (SCH) as well as barriers to remote AS to satisfy The Joint Commission (TJC)'s AS standard. This was a prospective chart review and time study conducted in patients identified by a clinical decision support application as potential opportunities for antimicrobial therapy modification at a SCH between December 12, 2016, and March 31, 2017. Potential interventions were communicated electronically to the clinical pharmacy specialist, who would then communicate the recommendations to the patient's provider. The primary endpoint was a time study for stewardship activities. Secondary endpoints included describing barriers encountered to remote AS as well as a cost-benefit analysis of remote AS. The time study revealed an average of 11 alerts per day, 9 chart reviews per day, 8 interventions per day, and 5 minutes per chart. Seven hundred twenty-four alerts were evaluated with the most common alerts constituting opportunities for de-escalation (29%), targeted drugs (22%), positive blood cultures (18%), Intravenous (IV) to oral (PO) (17%), and antimicrobial renal monitoring (8%).Interventions were accepted (11%), accepted modified (6%), rejected (35%), or undetermined (48%). Barriers to implementation included workflow and indirect communication. For patients with accepted interventions, there was an average savings of $279.82 per patient in pharmacy charges. Through remote AS, a SCH can have an antimicrobial stewardship program that is in compliance with the basic elements of the TJC standard MM.09.01.01, performs daily chart review by an infectious diseases trained pharmacist to increase the quality of patient care, and achieves a mean savings of $279.82 in pharmacy charges and $1,126.26 in hospital charges per patient with accepted interventions.
本研究的目的是确定一家小型社区医院(SCH)开展抗菌药物管理(AS)活动所需的时间,以及远程AS的障碍,以满足联合委员会(TJC)的AS标准。这是一项前瞻性图表回顾和时间研究,研究对象为2016年12月12日至2017年3月31日期间在SCH被临床决策支持应用程序识别为抗菌治疗调整潜在机会的患者。潜在干预措施通过电子方式传达给临床药学专家,然后由专家将建议传达给患者的医疗服务提供者。主要终点是AS活动的时间研究。次要终点包括描述远程AS遇到的障碍以及远程AS的成本效益分析。时间研究显示,平均每天有11次警报、9次图表回顾、8次干预,每次图表花费5分钟。共评估了724次警报,最常见的警报构成了降阶梯机会(29%)、靶向药物(22%)、血培养阳性(18%)、静脉注射(IV)改为口服(PO)(17%)以及抗菌药物肾脏监测(8%)。干预措施被接受(11%)、接受修改(6%)、拒绝(35%)或未确定(48%)。实施障碍包括工作流程和间接沟通。对于接受干预的患者,每位患者的药房费用平均节省279.82美元。通过远程AS,SCH可以拥有一个符合TJC标准MM.09.01.01基本要素的抗菌药物管理计划,由经过传染病培训的药剂师进行每日图表回顾以提高患者护理质量,并且对于接受干预的患者,每位患者的药房费用平均节省279.82美元,医院费用平均节省1126.26美元。