Aldandan Ahmed, Almomen Ali, Alkhatib Abdulrahman, Alazzeh Ghaleb
Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of ENT, King Fahad Specialist Hospital, Ministry of Health, Dammam, Saudi Arabia.
Case Rep Pathol. 2019 Jan 2;2019:8201674. doi: 10.1155/2019/8201674. eCollection 2019.
Ewing's sarcoma (ES) is a highly malignant, small, round cell tumor that originates from the primitive neuroectodermal cells. Primary ES commonly occurs in early childhood or adolescence. It may present with skeletal and extraskeletal forms. The extraskeletal form is rarely encountered in the head and neck region and is extremely rare in the sinonasal tract. This is a case report of sinonasal ES in a 13-year-old female patient who presented with a 7-month history of right nasal obstruction, anosmia, intermittent epistaxis, snoring, and hearing loss. Clinical examination revealed a right nasal mass pushing the septum to the left side and extending to the nasopharynx. Endoscopic biopsy and histopathological analysis showed a small blue cell tumor suggestive of ES. The patient was treated with surgery, radiotherapy, and chemotherapy. After a follow-up of 5 years, the patient remains recurrence-free with excellent functional status and quality of life.
尤因肉瘤（ES）是一种高度恶性的小圆细胞肿瘤，起源于原始神经外胚层细胞。原发性ES常见于儿童早期或青少年期。它可表现为骨骼和骨骼外两种形式。骨骼外形式在头颈部区域很少见，在鼻窦道极为罕见。本文报告一例13岁女性鼻窦ES病例，患者有7个月的右侧鼻塞、嗅觉减退、间歇性鼻出血、打鼾及听力丧失病史。临床检查发现右侧鼻腔肿物将鼻中隔推向左侧并延伸至鼻咽部。内镜活检及组织病理学分析显示为提示ES的小蓝细胞肿瘤。患者接受了手术、放疗和化疗。随访5年后，患者无复发，功能状态和生活质量良好。
