Clinic of Gastroenterology, "Tsaritsa Yoanna - ISUL" University Hospital, Medical University of Sofia, Sofia, Bulgaria.
Eur Rev Med Pharmacol Sci. 2019 Jan;23(2):788-794. doi: 10.26355/eurrev_201901_16893.
In this study, we aimed to evaluate the role of serum trefoil factor 3 (TFF3) as a biomarker of disease activity in patients with inflammatory bowel disease (IBD) and to compare TFF3 values with those of fecal calprotectin (FC).
128 patients with IBD were divided into four groups: 1) active ulcerative colitis (UC); 2) quiescent UC; 3) active Crohn's disease (CD); 4) quiescent CD. The serum levels of TFF3 and FC levels were assessed in all patients and 16 controls.
Patients with active UC had higher TFF3 levels than those with quiescent UC (p<0.001), those with active (p<0.001) or quiescent CD (p<0.001) and controls (p <0.001). We found a correlation between TFF3 and FC values in patients with active (r = 0.478, p = 0.006) and quiescent UC (r=0.528, p=0.002). TFF3 levels correlated with endoscopic activity in UC (evaluated by UC Endoscopic Index of Severity - UCEIS) (r=0.662, p<0.001).
Serum TFF3 is able to identify patients with active UC. It could be used as a marker to predict disease activity in patients with UC.
本研究旨在评估血清三叶因子 3（TFF3）作为炎症性肠病（IBD）患者疾病活动的生物标志物的作用，并将 TFF3 值与粪便钙卫蛋白（FC）进行比较。
128 例 IBD 患者分为四组：1）活动期溃疡性结肠炎（UC）；2）缓解期 UC；3）活动期克罗恩病（CD）；4）缓解期 CD。所有患者和 16 名对照均评估了 TFF3 和 FC 水平。
活动期 UC 患者的 TFF3 水平高于缓解期 UC 患者（p<0.001）、活动期（p<0.001）或缓解期 CD 患者（p<0.001）和对照组（p<0.001）。我们发现活动期和缓解期 UC 患者的 TFF3 值与 FC 值之间存在相关性（r=0.478，p=0.006；r=0.528，p=0.002）。TFF3 水平与 UC 的内镜活动相关（用 UC 内镜严重程度指数评估 - UCEIS）（r=0.662，p<0.001）。
血清 TFF3 能够识别活动期 UC 患者。它可以用作预测 UC 患者疾病活动的标志物。
