Parrish Joy B, Fields Emily
Department of Neurology, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 1001 Main St., Buffalo, NY 14203, USA.
Department of Psychology, Roosevelt University, 430 S Michigan Ave, Chicago, IL 60605, USA.
Children (Basel). 2019 Feb 4;6(2):21. doi: 10.3390/children6020021.
Pediatric-onset multiple sclerosis (POMS) is relatively rare, but as technology and neuroimaging advance, an increasing number of cases are identified, and our understanding of how multiple sclerosis (MS) impacts the developing brain improves. There are consistent findings in the literature highlighting the impact of MS and other demyelinating diseases on cognitive functioning and cognitive development. We also have a better understanding of how POMS impacts psychosocial functioning and functional outcomes in daily living. This paper hopes to review findings associated with cognitive and psychosocial functioning in patients with POMS, as well as explore more recent advances in the field and how they relate to cognitive and psychosocial outcomes. We also discuss the ongoing need for future studies with a focus on better understanding deficits and disease correlates, but also preventative measures and potential rehabilitation.
儿童期多发性硬化症（POMS）相对罕见，但随着技术和神经影像学的发展，越来越多的病例被发现，我们对多发性硬化症（MS）如何影响发育中的大脑的认识也有所提高。文献中有一致的研究结果强调了MS和其他脱髓鞘疾病对认知功能和认知发展的影响。我们也更好地理解了POMS如何影响心理社会功能和日常生活中的功能结局。本文希望回顾与POMS患者认知和心理社会功能相关的研究结果，探讨该领域的最新进展以及它们与认知和心理社会结局的关系。我们还讨论了未来研究的持续需求，重点是更好地理解缺陷和疾病相关性，以及预防措施和潜在的康复方法。
